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Updated: Mar 8, 2026

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
11:44

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

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氨酸-11的泛基化驱动了通过cGAS-STING和Toll-like受体3和4的I/III型干扰素诱导

Alexis Betrancourt1,2,3, M Talha Cinko1,2, Ana Beatriz Varanda1,2

  • 1Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.

Nature cell biology
|March 6, 2026
PubMed
概括

E3结合酶ANKIB1使用K11结合的泛化来激活TANK结合激酶1 (TBK1) 和干扰素 (IFN) 生产. 这一途径对于涉及托尔类受体3 (TLR3) 和IFN基因循环GMP-AMP合成酶刺激器 (cGAS-STING) 的免疫反应至关重要.

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