便微生物群移植在炎症性肠病:一个系统的审查和随机对照试验 (2020-2025) 的元分析 (2020-2025)
Sania Ikram1, Muneeb Ullah2, Juho Lee3
1Section of Nanomedicine, Department of Biological Sciences, National University of Medical Sciences, Islamabad, Punjab, Pakistan.
Inflammopharmacology
|March 6, 2026
概括
便微生物种移植 (FMT) 显著改善了炎症性肠病 (IBD) 的临床和内镜缓解,特别是性结肠炎 (UC). 然而,维持缓解的长期安全性和有效性需要在更大的试验中进一步调查.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 微生物组研究 微生物组研究
- 临床治疗学 临床治疗学
背景情况:
- 便微生物种移植 (FMT) 是一种新兴的炎症性肠病 (IBD) 治疗方法,包括性结肠炎 (UC) 和克罗恩病 (CD).
- 现有的随机对照试验 (RCT) 提供了关于FMT对IBD的安全性和有效性的碎片化证据.
- 本系统性审查和元分析综合了目前关于IBD微生物组干预措施的证据.
研究的目的:
- 评估FMT在诱导IBD患者临床缓解和内镜改善方面的疗效.
- 评估FMT的安全性,包括不良事件.
- 检查 FMT 在 IBD 中维持缓解的潜力.
主要方法:
- 在PubMed,Cochrane CENTRAL和Embase系统搜索2020年1月至2025年5月期间发表的RCT.
- 包括的研究比较了捐赠者FMT与安慰剂,自主FMT或成人IBD患者的标准治疗.
- 用R进行了元分析,计算了95%置信区间 (CI) 的聚合几率比率 (ORs).
主要成果:
- 与对照组相比,FMT显著增加了临床缓解率 (OR=3.24) 和内镜反应 (OR=6.80),特别是在UC.
- 严重的不良事件在FMT组中更频繁,但没有达到统计学意义.
- 证据证明FMT在维持缓解方面的有效性是有限的,并且在各个研究中不一致.
结论:
- 基于微生物组的疗法,特别是FMT,显示出显著的潜力,可以改善IBD的临床和内镜结果,特别是UC.
- 关于FMT的长期安全性和维护疗效仍然存在不确定性.
- 需要进一步的大规模,针对疾病的RCT来证实研究结果,并确定FMT在IBD管理中的作用.
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