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Updated: Mar 8, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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在主要精神疾病中,多基因风险和与大脑结构的关联的转录组知情大脑绘图

Alessio Giacomel1,2,3, Timothy R Powell4, Rodrigo R R Duarte4,5

  • 1Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Alessio.giacomel@kcl.ac.uk.

Molecular psychiatry
|March 6, 2026
PubMed
概括

这项研究将精神疾病的遗传风险与使用成像转录学学的大脑结构变化联系起来. 它发现特定的大脑区域显示了转录的脆弱性,导致主要抑郁症,精神分裂症和多动症的解剖学差异.

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