尿路分泌的异常昼夜模式和慢性病进展的慢性病
Lingling Liu1, Sirui Liu1, Menglei Jv1
1Department of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, 519000, China.
BMC nephrology
|March 6, 2026
概括
尿路分泌的日夜比较低与慢性病 (CKD) 的进展有关. 这一发现表明,该比率可能有助于识别患有恶化功能风险较高的患者.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 循环节生物学 循环节生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 尿路分泌的异常昼夜模式与高血压和器官损伤有关.
- 尿路分泌的昼夜模式和慢性病 (CKD) 的进展之间的关联仍然不清楚.
研究的目的:
- 为了研究尿液内分泌的日夜比和CKD的进展之间的关系.
- 为了确定白天到夜晚的尿分泌比率是否可以作为CKD进展的预测标记.
主要方法:
- 对1604名患有CKD的参与者进行了回顾性队列研究.
- 用分别采集的白天和夜间尿样分析尿中分泌的日夜比率.
- 主要结局:≥30%降低EGFR或启动替代疗法. 二次结局:EGFR降低≥50%或启动置换疗法.
主要成果:
- 主要和次要结局分别发生在319名和247名患者身上,超过5710.2人年.
- 卡普兰-梅尔分析显示,较低的白天到夜间尿分泌率与初级和二级结局 (P <0.05) 之间存在显著的关联.
- 多变量分析显示,日夜尿分泌比率的最低四分位数与初级结果的风险增加2.29倍,二次结果的风险增加2.42倍,与最高四分位数相比.
结论:
- 尿路分泌的异常昼夜模式,以降低白天到夜间的比率来表示,与CKD进展有关.
- 尿中分泌的日夜比可能是识别患者中CKD进展的有价值生物标志物.
- 这些发现强调了昼夜节律对脏健康和疾病进展的重要性.
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