在经过手术治疗的骨盆骨折后,在工作年龄的患者中长期使用阿片类药物:患病率,人口统计和多变量预测模型
Elina Ekman1, Rasmus Liukkonen2, Aleksi Reito2
1Department of Orthopaedics and Traumatology, Turku University Hospital and the University of Turku, Turku, Finland.
European journal of pain (London, England)
|March 7, 2026
概括
在骨盆骨折手术后,长期使用阿片类药物很常见,在手术后三个月影响超过40%的患者. 手术前使用阿片类药物是持续使用的最强预测因素.
科学领域:
- 整形外科 整形外科 整形外科
- 疼痛管理 疼痛管理
- 公共卫生 公共卫生
背景情况:
- 骨盆骨折 (PF) 是严重的伤害,往往导致长期使用阿片类药物.
- 了解阿片类药物使用模式 手术后的PF治疗对于管理慢性疼痛和成至关重要.
研究的目的:
- 在芬兰劳动年龄人口中,检查骨盆骨折外科治疗后的阿片类药物使用情况.
- 为了确定骨盆骨折手术后长时间使用阿片类药物的预测因素.
主要方法:
- 2015-2021年全国注册数据确定了233名芬兰患者 (18-65岁) 接受PF手术.
- 分析了人口统计数据,抑郁症,创伤机制,阿片类药物购买和社会经济地位.
- 后勤和Poisson零膨胀 (ZIP) 回归模型确定了长期使用阿片类药物的预测因素 (定义为在术后3个月后填写的>1处方).
主要成果:
- 40.3%的患者在手术后3-12个月使用至少一种阿片类药物处方.
- 手术前使用阿片类药物是术后使用阿片类药物的最重要的预测因素 (aOR 6.59).
- 抑郁症在3-12个月后显示出适度的影响 (aOR2.08);回归模型的预测性能较低.
结论:
- 经过手术治疗的骨盆骨折后,长期使用阿片类药物很普遍.
- 手术前使用阿片类药物和抑郁症是长期术后使用阿片类药物的关键预测因素.
- 针对术前阿片类药物使用和抑郁症的干预措施可以减轻长期阿片类药物依赖.
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