线粒体DNA遗传变异与抑郁症和焦虑症的关联在患有系统性狼的中国患者中
Qiqun Zong1,2, Yue Li1,2, Yuxin Wang1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
International journal of rheumatic diseases
|March 7, 2026
概括
线粒体DNA (mtDNA) 的遗传变异,包括SNV和CNV,与中国患者患有全身性红斑狼 (SLE) 的抑郁和焦虑有关. 某些变异也可能影响SLE患者焦虑症状的改善.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,与抑郁症和焦虑症等心理并发症有关.
- 线粒体功能障碍和线粒体DNA (mtDNA) 的遗传变异已与各种疾病有关,但它们在SLE相关的心理健康状况中的作用尚未完全理解.
研究的目的:
- 调查不同类型的线粒体DNA (mtDNA) 遗传变异 (SNV,InDels,CNV) 与被诊断患有SLE的中国患者中抑郁和焦虑的患病率之间的联系.
- 探索这些mtDNA变异对12周随访期间抑郁和焦虑症状改善的潜在影响.
- 检查特定mtDNA变体与与细胞压力和炎症相关的关键生物标志物之间的关系,例如活性氧物种 (ROS),腺三酸盐 (ATP),介质素-6 (IL-6) 和介质素-1β (IL-1β).
主要方法:
- 这是一项两阶段的研究,涉及530名患有SLE的中国患者,分析mtDNA单核酸变异 (SNVs) 和插入/删除 (InDels).
- 另外一组499名SLE患者被招募来评估mtDNA复制数变异 (CNVs).
- 患者被监测了12周,以评估抑郁和焦虑症状的变化,以及测量ROS,ATP,IL-6和IL-1β水平.
主要成果:
- 在D环区域的两个特定的mtDNASNV (C16291T,A16399G) 与SLE患者的抑郁症有显著的关联.
- 在COX3基因和D环区域的另外两种mtDNASNV (T9950C,T16140C) 显示出与SLE患者的焦虑有显著的关联.
- 在某些子组中,mtDNA CNV 与抑郁和焦虑有关,特定变体 (T9950C,T16140C) 与焦虑改善相关. 在超重/肥胖SLE患者 (BMI ≥24) 中, mtDNA CNVs与焦虑改善之间注意到了反向的U形关联.
- 患有COX3基因变异的患者表现出ROS和IL-6水平增加,ATP水平降低.
结论:
- 线粒体DNA遗传变异,包括SNV和CNV,可能与SLE中国患者的抑郁和焦虑的发展有关.
- 这些发现表明mtDNA遗传变异可能作为SLE抑郁症和焦虑症的潜在生物标志物,并为管理这些心理并发症提供新的治疗点.
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