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儿科肝移植:一个单一中心的回顾性研究

Xiaohu Zhou^1,2,3,4,5,6, Hanqi Yu^1,2,3,4,5,6, Qiang Sun^1,2,3,4,5,6

¹Department of Hepatobiliary and Pancreatic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Pediatric transplantation

|March 7, 2026

概括

中国的儿科肝移植 (LT) 显示出高生存率,与全球标准相美. 这项研究详细介绍了我们中心的结果,强调了活体供体和分裂肝脏技术对末期肝脏疾病的进步.

科学领域:

肝病学肝病学是一种肝病学.
儿科手术儿科手术
移植免疫学移植免疫学

背景情况:

肝移植 (LT) 为儿科末期肝病提供拯救生命的治疗方法.
在中国大陆观察到儿科LT的显著进展.
这项研究描述了我们中心儿科LT的现状.

研究的目的:

报告我们中心儿科肝移植的结果.
分析接受者和捐赠者的特征,手术程序和并发症.
评估生存率和确定影响死亡率的因素.

主要方法:

从2019年7月到2023年7月,对116名儿科LT接受者的回顾性审查.
对接受者/捐赠者的人口统计数据,手术前数据,手术内细节和移植后并发症的分析.
卡普兰-梅尔生存分析与日志等级测试.

主要成果:

进行了116次儿科肝试验:57次活体供体 (LDLT),57次分裂肝 (SLT),2次全肝 (WLT).
一年和三年总生存率分别为93.1%和92.2%.
血管 (6.03%) 和胆道 (2.59%) 的并发症被注意到;死亡原因包括感染和PTLD.

结论:

中国的儿科LT在国际标准相当的结果显示了实质性的进展.
从已故的大脑死亡捐赠者身上进行的分裂肝移植显示了与LDLT相似的存活率.
需要对术后管理和免疫抑制策略进行进一步的研究,以提高存活率.

关键词:

活体捐赠者的肝脏移植移植儿科肝移植手术儿科肝移植手术切割肝脏移植移植切割肝脏移植幸存率幸存率生存率

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