皮佩拉功能化纳米颗粒使肥胖小鼠能够提供口服胰岛素
Yuxue Cao1,2, Xiaofan Jiang1, Md Moniruzzaman3
1School of Pharmacy and Pharmaceutical Sciences, The University of Queensland, Brisbane, QLD, Australia.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 7, 2026
概括
这项研究开发了与1-phenylpiperazine (PPZ) 接种的新型纳米颗粒,以增强口服生物递送. 这些纳米粒子安全地提高了胰岛素的肠道吸收,为注射提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 生物药物是关键的治疗药物,但由于口服吸收不佳,往往需要通过肠道给药.
- 目前使用纳米粒子或化学透增强剂 (PE) 的口服输送方法在有效性和安全性方面存在局限性.
- 1-phenylpiperazine (PPZ) 是一种有效的PE,但在治疗剂量时表现出毒性.
研究的目的:
- 开发一种安全有效的基于纳米粒子的透增强剂,用于口服生物递送.
- 调查PPZ移植的纳米颗粒在增强宏分子肠道透中的有效性.
- 通过使用这些新型纳米颗粒来评估口服胰岛素的体内安全性和有效性.
主要方法:
- 合成的二氧化纳米颗粒与1-phenylpiperazine (PPZ) 接种在一起.
- 在试验室中使用Caco-2单层和共同培养模型评估宏分子透率.
- 在高脂肪饮食小鼠模型中评估了小鼠FITC-dextran-4 kDa的体内透率和胰岛素吸收.
主要成果:
- 在没有明显的毒性的情况下,PPZ移植的纳米颗粒在体外显著增强了胰岛素的透性.
- 在体内研究表明,与裸体纳米颗粒相比,FITC-dextran-4 kDa透率得到改善.
- 在小鼠中,用-PPZ纳米颗粒口服胰岛素导致持续的血糖降低,没有观察到毒性.
结论:
- PPZ植入的纳米颗粒代表了一种安全有效的透增强剂,用于口服生物递送.
- 这种新的方法有可能改善胰岛素和其他生物制剂的口服.
- 开发的系统克服了现有的PE的局限性,为注射提供了一个有希望的替代方案.
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