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Updated: Mar 9, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

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重编程先天免疫力以克服雌激素受体阳性乳腺癌中的内分泌抵抗

Siti Nur Hasyila Muhammad1, Maryam Azlan2, Agustine Nengsih Fauzi1,3

  • 1Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

International journal of cancer
|March 7, 2026
PubMed
概括

瘤微环境中的先天性免疫细胞通过STAT3途径抑制抗瘤免疫力,驱动ER+乳腺癌中的内分泌抵抗. 抑制STAT3可能会恢复对内分泌疗法的敏感性.

关键词:
有ER阳性的乳腺癌.内分泌耐药性的内分泌抵抗.具有天生的免疫力.自然杀手细胞是自然杀手细胞.与瘤相关的巨细胞.

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