卫生和疾病的标准:组织特异性行动和信号网络
1Xi'an Key Laboratory of Innovative Drug Research for Heart Failure, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an, 710069, China.
概括
流星类 (Metrnl) 是一种新型分泌蛋白质,具有广泛的组织表达和多样化的功能. 这篇评论探讨了Metrnl的情况.
科学领域:
- 内分泌学和新陈代谢学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 流星类 (Metrnl) 是一种与流星 (Metrn) 相同的新型分泌蛋白质.
- 最初与脂肪组织和代谢调节有关,现在已知Metrnl在各种组织中表达,包括神经系统,屏障组织和骨肌肉.
- 梅特林表现出性效应,作为一种阿迪波金,免疫调节因子和细胞保护媒介.
研究的目的:
- 为Metrnl的组织特异性作用提供全面的概述.
- 总结调节铁路活动的关键信号通路.
- 检查Metrnl在健康和疾病中的作用,特别是它在人类疾病中的病理参与.
主要方法:
- 关于Metrnl现有研究的文献综述.
- 在不同组织中分析Metrnl的表达模式.
- 综合有关Metrln的功能角色和信号通路的数据.
主要成果:
- Metrnl表现出多种功能,包括代谢调节,免疫调节和细胞保护.
- 广泛的表达强调了Metrnl在脂肪组织之外的系统重要性.
- 有证据表明,Metrnl与各种人类疾病的病理学有关.
结论:
- Metrnl 是一种关键的多功能蛋白质,在各种生理和病理过程中具有重大影响.
- 了解Metrnl的组织特异性作用和信号通路对于治疗开发至关重要.
- 对Metrnl在人类疾病中的作用的进一步研究有望为新的治疗策略提供希望.
更多相关视频
07:51Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
18.1K
11:44A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Published on: September 27, 2017
11.9K
相关概念视频
Autocrine Signaling
52.6K
Autocrine signaling is one of the many signaling mechanisms that function inside multicellular organisms to carry out intercellular communication. In this type of signaling mechanism, the same cell that secretes an extracellular signaling molecule also expresses the receptors to bind and respond to that signaling molecule.
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
Autocrine Signaling in Macrophages
Under normal physiological conditions, autocrine signaling is essential for maintaining homeostasis. This process is well characterized in...
52.6K
Signal Transduction: Overview
12.2K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...
12.2K
Interactions Between Signaling Pathways
7.6K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.6K
The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
TGF - β Signaling Pathway
10.8K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K
Notch Signaling Pathway
6.8K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.8K
