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免疫生物标志物预测急性-慢性肝衰竭中对G-CSF的反应:来自GRAFT试验子研究的结果

Katrin Splith^1,2, Nadja Berndt³, Philipp K Haber³

¹Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. splith.katrin@mh-hannover.de.

Hepatology international

|March 7, 2026

概括

在急性至慢性肝衰竭 (ACLF) 中,花细胞群刺激因子 (G-CSF) 的疗效尚不确定. 像VEGF-A和CD39+淋巴细胞这样的生物标志物可以预测ACLF患者的预后和G-CSF治疗反应.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
生物标志物发现发现

背景情况:

在治疗急性至慢性肝衰竭 (ACLF) 中,花细胞殖民地刺激因子 (G-CSF) 的有效性受到争议.
这项研究旨在确定ACLF的预后生物标志物,并预测对G-CSF治疗的反应.

研究的目的:

在ACLF患者中确定预后生物标志物.
为了确定预测对G-CSF治疗反应的标志物.

主要方法:

参与79名ACLF患者的GRAFT研究 (NCT02669680) 的二次分析.
对血液样本进行细胞,细胞因子,细胞外颗粒和无细胞DNA的分析.
探索性考克斯回归和免疫细胞群的无监督层次聚类.

主要成果:

与对照组相比,ACLF患者表现出高水平的促炎细胞因子和特定的免疫细胞群.
血VEGF-A水平在基线预测无移植生存 (AUC:0.70).
层次聚类确定了一个患者子集,在G-CSF (102 vs. 16天) 上有改善的生存率.
更高的CD39+淋巴细胞百分比独立预测了G-CSF后不良结果 (HR:1.05).

结论:

VEGF-A是ACLF预后的一个潜在生物标志物.
层次细胞聚类可以确定从G-CSF治疗中受益的ACLF患者.
淋巴细胞上的CD39表达可能有助于治疗分层,需要进一步验证.

关键词:

在ACLF中,ACLF是ACLF.CD39 CD39 是一个细胞因子 (cytokines) 是一种细胞因子.颗粒细胞殖民地刺激因子造血干细胞造血干细胞造血干细胞肝功能衰竭肝功能衰竭肝脏的再生再生原始细胞是原始细胞.purinergic 信号传递纯能信号传递系统性炎症是一种系统性炎症.在VEGF-A的基础上.

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