评估VELscope在口腔癌和癌前查中的作用:一个范围审查
Kajal Samantaray1, Ayush Lohiya1, Tushar Kumar1
1Department of Public Health, Kalyan Singh Super Speciality Cancer Institute, Lucknow, Uttar Pradesh, India.
Asian Pacific journal of cancer prevention : APJCP
|March 7, 2026
概括
视觉增强损伤范围 (VELscope) 在检测口腔癌方面表现有前途,特别是与其他方法相结合时. 然而,其独立使用受到低特异性的限制,需要进一步研究以获得最佳的临床应用.
科学领域:
- 口腔瘤学 在口腔瘤学
- 诊断成像诊断成像的使用
- 公共卫生 公共卫生
背景情况:
- 口腔癌仍然是一个重要的全球健康问题,晚期诊断加剧了死亡率,特别是在LMICs.
- 使用组织自光学的VELscope在识别可疑的口腔病变方面提供了潜在的帮助.
- 本综述系统评估了VELscope在检测前恶性和恶性口腔病变方面的有效性.
研究的目的:
- 系统地绘制VELscope在检测前恶性和恶性口腔病变方面的有效性现有的证据.
- 评估VELscope的诊断准确性,单独或与其他工具结合使用.
主要方法:
- 使用Arksey和O'Malley框架和JBI方法论进行的范围审查,遵守PRISMA-ScR指南.
- 从2010年1月到2024年12月,搜索了四个主要的数据库 (PubMed,Embase,Scopus,Cochrane图书馆) 的数据.
- 包括27项研究,包括3875名参与者,以评估VELscope的诊断准确性.
主要成果:
- 在20项研究中,VELscope显示出高灵敏度 (>75%),但特异性差异很大 (15%-100%),其中16项研究低于75%.
- 诊断准确度受到临床医生的培训和经验的影响;低的特异性导致了假阳性和不必要的转诊.
- 当VELscope与常规口腔检查 (COE),多氨酸蓝色试验 (TBT) 或拉曼光谱学相结合时,准确性显著提高.
结论:
- VELscope是COE的一个有价值的辅助工具,用于改善高风险人群中的病变检测.
- 由于特异性较低,VELscope的独立诊断使用受到限制,因此需要使用多模式查协议.
- 优化临床效用需要有针对性的临床医师培训和进一步研究以社区为基础的查和成本效益.
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