只有在每葡萄糖120ATP的需求能量:对林奇的回复
1Institute of Molecular Evolution, Heinrich Heine University Düsseldorf, 40225, Düsseldorf, Germany.
Biochimica et biophysica acta. Bioenergetics
|March 7, 2026
概括
林奇的细胞能量计算膨胀了腺三酸盐 (ATP) 的需求,忽视了ATP的供应. 这种热力学不可能使他的对线粒体和进化中的内共生学的批评无效.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 进化生物学 进化生物学
背景情况:
- 林奇最近的一篇论文提出了对细胞生物合成成本 (腺三酸盐/ATP需求) 的夸张估计.
- 这些估计表明大肠杆菌每葡萄糖需要>100个ATP,线粒体每葡萄糖需要>240个ATP.
- 膨胀的数字源于仅考虑ATP需求而忽视ATP供应,这是生物能源学的一个关键方面.
研究的目的:
- 为了将林奇计算的ATP需求与实验室测量大肠杆菌中的ATP供应进行比较.
- 为了证明林奇提出的细胞能量需求的热力学不可能.
- 为了驳斥林奇基于错误的能量计算对线粒体和内共生的批评.
主要方法:
- 应用了细胞生长的热力学原理.
- 实验室测量了大肠杆菌细胞分裂期间的ATP供应.
- 计算的ATP需求与测量的ATP供应进行了比较.
主要成果:
- 林奇的计算需要大肠杆菌合成大约120个ATP每葡萄糖.
- 对于大肠杆菌来说,这种ATP合成水平在热力学上是不可能的.
- 这种差异凸显了仅需能源评估中的关键缺陷.
结论:
- 林奇专注于ATP需求,忽视供应,导致了热力学上不可能的结论.
- 林奇对线粒体和内共生提出的激烈论点是毫无根据的.
- 准确的生物能评估需要考虑ATP的供应和需求.
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