通过有针对性的感染预防和控制,在高风险的兽医医院单位减少产生卡巴酶的格拉姆阴性细菌
Chavin Leelapsawas1, Chutirat Torsahakul2, Nicole Sirisopit Mehl3
1Department of Veterinary Microbiology, Faculty of Veterinary Science, Chulalongkorn University, Henri-Dunant Road, Pathumwan District, Bangkok 10330, Thailand.
针对性感染预防和控制 (IPC) 干预措施显著减少了生产卡巴酶的グラム阴性细菌 (CP-GNB) 的污染和在兽医医院的殖民. 这些发现凸显了IPC策略在控制动物卫生保健环境中的抗菌素耐药细菌方面的有效性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染病控制和控制传染病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 卡巴酶产生格拉姆阴性细菌 (CP-GNB) 在医疗机构,包括兽医医院,构成重大威胁.
- 高风险单位,如重症监护,住院病房和手术室,特别容易受到CP-GNB污染和殖民.
- 了解兽医环境中CP-GNB的流行和传播动态对于有效控制至关重要.
研究的目的:
- 评估针对性感染预防和控制 (IPC) 干预措施对CP-GNB污染和殖民的影响.
- 评估IPC策略在降低高风险兽医医院单位中CP-GNB的有效性.
主要方法:
- 在一家兽医医院进行了为期十个月的准实验纵向研究.
- 包括环境表面的干预前,干预后和干预后的采样期,直肠拭子和临床标本.
- 用分子分析来识别CP-GNB菌株及其分布.
主要成果:
- 在重症监护病房 (64.6%),住院病房 (80.0%) 和手术室 (39.3%) 观察到高基线CP-GNB污染率.
- 在干预之前,患者殖民率在CCU为55.0%,在IPD为45.0%.
- IPC干预导致CP-GNB污染 (40.4%-87.8%) 和整个单位的殖民 (28.6%-36.4%) 显著减少 (p < 0.001).
结论:
- 有针对性的IPC干预措施在减少兽医医院环境中的CP-GNB污染和殖民方面非常有效.
- 医院监测和战略IPC实施对于控制动物患者中抗菌素耐药细菌的传播至关重要.
- 这项研究表明IPC在减轻兽医中CP-GNB的威胁方面的重要性.
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