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刺激性肠综合征的血清和便标志物:系统审查和元分析

Grace L Burns¹, Freya Roberts², Jasmine A Wark¹

¹College of Health, Medicine and Wellbeing, The University of Newcastle, Callaghan, Australia; Immune Health Research Program, Hunter Medical Research Institute, New Lambton Heights, Australia; NHMRC Centre of Research Excellence in Transforming Gut Health, New Lambton Heights, Australia.

|March 7, 2026

概括

这次系统性审查和元分析确定了刺激性肠综合征 (IBS) 的关键生物标志物. 血清细胞因子和便calprotectin的升高显示出对诊断IBS和区分其与有机疾病的希望.

科学领域:

胃肠道学和免疫学
微生物组研究微生物组研究
生物标志物发现发现

背景情况:

刺激性肠综合征 (IBS) 越来越多地被认为具有超出功能障碍分类的生物学基础.
尽管取得了进展,但IBS的客观诊断生物标志物仍然难以捉摸,严重依赖症状报告和排除.
这项研究旨在系统地审查和元分析IBS的血清和便生物标志物.

研究的目的:

在血清和便样本中识别出针对刺激性肠综合征 (IBS) 的一致和可靠的生物标志物.
为了区分IBS患者与健康对照和有机胃肠道疾病患者.
探索潜在的生物标志物,以区分IBS亚型.

主要方法:

在主要的医学数据库 (Medline,EMBASE,Cochrane,Web of Science,Scopus) 中进行了全面的系统搜索.
包括124项涉及14930名IBS患者,7544名健康对照和4317名有机疾病患者的研究.
分析使用标准化平均差异 (SMD) 与随机效应模型来评估血清和便标志物.

主要成果:

对IBS与健康对照的关键血清区分器包括TNF-α,IL-6和IFN-γ的升高.
与对照组相比,IBS患者的便calprotectin显著高于控制组,而酸则较低.
血清白蛋白和便calprotectin区分IBS和有机疾病;IL-6和白蛋白区分IBS与腹 (IBS-D).

结论:

在IBS患者中,外周细胞因子的升高表明上皮质的透性增加,并可能导致亚组的分化.
在IBS中便calprotectin的高,虽然低于有机疾病,但提供了一个诊断标记.
在IBS患者中发现的生物特征可能有助于临床诊断和阐明疾病机制.

关键词:

生物标志物生物标志物血液血液血液血液便标记物便标记物刺激性肠综合征是什么意思系统性审查系统性审查

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