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Updated: May 6, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

DLPFC rTMS在戒烟方面比假或轨道前额刺激更有效,并改变前脑活动:一项双盲,假控制的随机临床试验

Xingbao Li¹, Kevin A Caulfield¹, Matthew J Carpenter²

¹Brain Stimulation Division, Department of Psychiatry, Medical University of South Carolina, Charleston, SC, 29425, United States; Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, 29425, United States.

Journal of psychiatric research

|March 7, 2026

概括

在左背侧前额叶皮层进行重复性横磁性刺激 (rTMS) 显著减少了吸烟,而不是准奖励回路. 这表明加强执行控制是rTMS辅助戒烟的关键.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
成药物药物药物药物

背景情况:

重复性横磁性刺激 (rTMS) 是一个有前途的戒烟帮助.
对于烟草使用障碍 (TUD) 的rTMS疗效背后的神经机制尚未完全理解.
这项研究调查了rTMS是否增强执行控制或抑制奖励活动以减少吸烟.

研究的目的:

为了比较刺激性和抑制性rTMS对TUD患者不同脑电路的影响.
为了确定rTMS是否通过改善执行控制或调节奖励处理来减少吸烟.
为了阐明rTMS用于戒烟的神经机制.

主要方法:

这是一项双盲,模拟控制试验,涉及46名TUD患者.
参与者接受了15次fMRI指导的,E场剂量的rTMS:假的,在左侧脊侧前额叶皮层 (L-DLPFC) 上进行10 Hz,或在左侧中间轨道前额叶皮层 (L-mOFC) 上进行1 Hz.
主要结局包括减少每天吸烟 (CPD) 和在fMRI扫描上BOLD活动的变化.

主要成果:

与1赫兹L-mOFC和假装组相比,10赫兹L-DLPFC组显示出明显更大的CPD减少 (分别为-11.14和-4.92和-6.43).
rTMS到L-DLPFC增加了前额活动和减少了轨道前额活动.
减少CPD与增强的L-DLPFC激活相关.

结论:

通过10 Hz rTMS在L-DLPFC上加强执行控制,比调节奖励电路更有效地减少吸烟.
加强奖励处理的前额调节似乎是rTMS诱导的戒烟的关键机制.
这些发现支持L-DLPFC刺激作为TUD治疗的有针对性的方法.

关键词:

在 DLPFCFC 中,执行控制电路执行控制电路图像引导的TMS是指导图像的奖励电路是一个奖励电路.戒烟的方法是戒烟.烟草使用障碍烟草使用障碍在 mOFC 中,mOFC 在 mOFC 中

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