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病毒与宿主之间的代谢相互作用:SGIV诱导的蛋白质乳糖化抑制病毒传播

Mingming Zhao¹, Jiaxi Li¹, Mingzhu Liu¹

¹Guangxi Academy of Marine Sciences, Guangxi Academy of Sciences, Guangxi Key Laboratory of Aquatic Biotechnology and Modern Ecological Aquaculture, Guangxi Engineering Research Center for Fishery Major Diseases Control and Efficient Healthy Breeding Industrial Technology, Guangxi, Nanning, P.R. China.

Fish & shellfish immunology

|March 7, 2026

概括

新加坡伊利多病毒 (SGIV) 感染改变了宿主细胞的新陈代谢和蛋白质乳酸化. 外源乳酸抑制SGIV复制,并显示抗菌性质,提供新的治疗途径.

科学领域:

水生动物的健康状况.
病毒学病毒学
分子生物学分子生物学
代谢学代谢学代谢学

背景情况:

新加坡鱼皮病毒 (SGIV) 对水产养殖构成重大威胁.
了解宿主-病原体相互作用对于开发有效治疗方法至关重要.
关于SGIV感染期间代谢和蛋白质修饰变化的知识有限.

研究的目的:

为了研究SGIV感染后 (GS) 细胞中的代谢和蛋白质修饰变化.
阐明蛋白质乳糖化在SGIV病原发生中的作用.
评估乳酸作为抗病毒和抗菌剂的潜力.

主要方法:

对感染SGIV的GS细胞进行了转录和蛋白质组分析.
乳酸蛋白质组分析以确定乳酸蛋白质.
功能性实验评估外源乳酸盐对SGIV复制和细菌生长的影响.

主要成果:

在GS细胞中,SGIV感染诱导了显著的乳酸积累和增加蛋白质乳酸化.
代谢重编程涉及氧化酸化的上调调节和失调的免疫路径.
蛋白质组分析显示了改变的应激反应,免疫调节和代谢蛋白质.
在参与细胞功能的关键蛋白质上观察到乳酸修饰.
外源乳酸表明显著抑制SGIV复制和广泛的抗菌活性.

结论:

SGIV感染重塑宿主细胞代谢和信号转导,通过乳酸代谢和蛋白质乳酸化.
蛋白质乳化在病毒感染期间对宿主细胞功能进行重新编程方面发挥着至关重要的作用.
乳酸盐具有双重抗病毒和抗菌特性,表明其具有治疗潜力.

关键词:

美国国务院GVIV 这是一种抗菌药物,具有抗菌作用.这是一种抗病毒药物.乳酸的积累乳酸的积累蛋白质的乳糖化蛋白质的乳糖化

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