在肺癌中通过空气空间传播:从争议到共识
Lili Qin1, Rui Zhang2, Yu Bai3
1Department of Pathology, Shaanxi Provincial People's Hospital, Xi'an 710068, China; Medical College of Yan'an University, Yan'an 716000, China.
Critical reviews in oncology/hematology
|March 7, 2026
概括
通过空气空间传播 (STAS) 是肺癌的特征,对诊断和预后很重要. 识别STAS有助于在早期肺腺癌的治疗决策.
科学领域:
- 在瘤学瘤学.
- 肺部医学 肺部医学
- 病理学 病理学 病理学
背景情况:
- 通过空气空间传播 (STAS) 是世卫组织于2015年引入的概念.
- STAS涉及癌细胞扩散到主要瘤之外的肺空气空间.
- 准确的诊断需要将STAS与人工物和其他细胞元素区分开来.
研究的目的:
- 审查STAS概念在肺癌中的演变.
- 评估STAS的临床意义和预后价值.
- 探索STAS与放射性特征和遗传突变的关联.
主要方法:
- 关于肺癌中STAS的综合文献综述.
- STAS与模仿者的病理差异化.
- 对不同肺癌亚型中STAS患病率的分析.
- STAS与放射性发现和驱动基因状态 (EGFR,ALK) 的相关性.
主要成果:
- 在肺腺癌中,STAS更常见,但在其他肺癌中也可能发生.
- STAS与EGFR阴性状态和ALK突变有关.
- STAS是第一阶段肺腺癌的预后预测剂.
结论:
- 诊断STAS需要仔细的病理评估.
- STAS对早期肺腺癌的预后有重大影响.
- 阳性STAS在IA阶段表明分叶切除;在IB阶段,它告知辅助治疗.
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