溶解微针可以有效地通过皮肤输送维生素B12,并减少内皮炎症
Mandeep Marwah1, Emmanuella Jumbo2, Pavanjeeth Balakrishnan1
1Aston Medical School, College of Health and Life Sciences, Aston University, UK.
Journal of pharmaceutical sciences
|March 7, 2026
概括
溶解微针提供了一种通过皮肤传递维生素B12的新方法. 这种方法有望通过改善吸收和生物活性来治疗恶性贫血和相关的血管问题.
科学领域:
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
背景情况:
- 维生素B12缺乏是一个严重的健康问题,经常导致恶性贫血和血管问题.
- 目前的维生素B12补充方法的吸收能力有限,特别是在缺乏内在因子的患者中.
- 需要先进的传递系统来克服这些吸收挑战.
研究的目的:
- 为了研究溶解微针的有效性,通过皮肤输送维生素B12.
- 评估通过皮肤透的维生素B12及其对内皮细胞的生物学影响.
- 评估微针作为治疗恶性贫血和血管功能障碍的潜力.
主要方法:
- 微针阵列使用聚乙烯罗利 (PVP K30) 和不同度和长度的三醇制造.
- 描述了微针的机械性能和插入效率.
- 在弗朗茨扩散细胞系统中使用切除的小鼠皮肤评估了维生素B12透率.
- 透维生素B12对EA.hy926内皮细胞的生物学影响通过测量IL-6表达和活性氧物种 (ROS) 生成来评估.
主要成果:
- 用15%的三醇和900μM长度配制的微针显示出最佳的机械性能和插入.
- 在24小时内,大约25%的维生素B12通过小鼠皮肤透.
- 透的维生素B12在体外有效地穿越了内皮细胞屏障,并显著降低了TNF-α诱导的IL-6表达和ROS产生.
结论:
- 溶解PVP-trehalose的微针是维生素B12的可行的通过皮肤输送系统.
- 这种方法确保持续释放并保持生物活性,为传统补充提供了替代方案.
- 该技术显示出对恶性贫血和相关的血管并发症进行最小侵入性治疗的潜力.
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