开发和特征的微藻基水凝与Nanochloropsis海洋和大豆蛋白分离物:抗氧化作用和酸输送的活性
Yunqiu Zhang1, See Hui Chew1, Wei Chuen Chan2
1China-ASEAN College of Marine Sciences, Xiamen University Malaysia, Bandar Sunsuria, 43900, Sepang, Selangor, Malaysia.
International journal of biological macromolecules
|March 7, 2026
概括
微藻增强大豆蛋白分离水凝用于药物输送. 纳诺克洛普西斯海洋注入的水凝显示改善的结构,抗氧化和抗菌性质,使它们成为有前途的生物医学载体.
科学领域:
- 生物材料科学 生物材料科学
- 海洋生物技术 海洋生物技术
- 药物输送系统 药物输送系统
背景情况:
- 微藻类,像海洋的Nannochloropsis,是生物活性化合物的丰富来源.
- 豆蛋白分离物 (SPI) 水凝在生物医学应用中具有潜力.
- 整合微藻可以增强用于药物输送的水凝特性.
研究的目的:
- 为了调查纳诺克洛普西斯海洋菌在SPI水凝中的结合.
- 评估复合水凝的结构,机械,抗氧化和抗菌性质.
- 评估这些水凝作为缓释药物递送系统的潜力.
主要方法:
- 豆蛋白分离物 (SPI) 水凝是用不同度的 Nannochloropsis oceanica 制备的.
- 使用扫描电子显微镜 (SEM) 和风湿学分析来描述水凝结构和粘性弹性.
- 使用总含量,总黄含量,ABTS和DPPH试验来评估抗氧化活性.
- 使用酸进行了药物加载和释放研究.
- 对大肠杆菌和Enterococcus faecalis进行了抗菌活性测试.
主要成果:
- SPI-N. oceanica (20%重量) 的水凝表现出规律的孔隙结构和增强的粘性弹性.
- 水凝的水溶性低,胀率高,抗氧化活性显著.
- 酸加载效率达到了64.60%,加载量为244.62 mg/g.
- 在24小时内观察到酸的受控释放.
- 对大肠杆菌和E. faecalis的抗菌活性在加酸加载后得到增强.
结论:
- 海洋的Nannochloropsis有效地增强了SPI水凝的性能.
- 复合水凝显示出作为缓慢释放药物的有效载体的潜力.
- 这项研究强调了微藻基生物载体在先进生物医学应用中的有用性.
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