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Updated: Mar 9, 2026

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凯姆菲罗尔通过准PTGS2-PGE轴来重新编程促炎性巨细胞的两极分化:一种传统的抗炎草药对的多omics解卷

Han Chen¹, Shuying Chen¹, Haixia Huang¹

¹Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Biochemical pharmacology

|March 7, 2026

概括

来自Chaihu-Baishao草药对的化合物Kaempferol通过向PTGS2-PGE2通路和重编程M1巨细胞,有效地治疗与代谢功能障碍相关的脂肪肝炎 (MASH).

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

代谢功能障碍相关的脂肪肝炎 (MASH) 是一种由亲炎性M1巨分化驱动的渐进性肝病.
目前对MASH的药物治疗方法有限,这凸显了对新型治疗策略的需求.

研究的目的:

解构MASH治疗中Chaihu-Baishao (CB) 草药对的分子机制.
识别和验证CB负责MASH改善的核心生物活性成分.

主要方法:

综合性多omics分析,包括转录学,以识别MASH驱动器.
网络药理学用于预测关键的生物活性化合物和标.
在体外和体内验证使用饮食诱导的MASH小鼠模型和巨细胞测试.
生物物理测试 (CETSA,DARTS,MST) 来确认分子相互作用.

主要成果:

转录基因分析确定M1巨细胞是MASH病变发生的核心.
预测Kaempferol将成为针对PTGS2 (COX-2) 的核心生物活性化合物.
凯姆菲罗尔直接抑制了PTGS2,抑制了M1巨分极和前列腺素E2 (PGE2) 的产生.
在MASH小鼠体内使用kaempferol改善了肝脏病理,并降低了肝脏PGE2水平.

结论:

凯姆菲罗尔是用于MASH治疗的CB草药对的主要生物活性成分.
凯姆菲罗尔通过准PTGS2-PGE2轴,重编程巨细胞极化来改善MASH.
凯姆菲罗尔是一种有前途的,机制定义的MASH治疗,具有转化潜力.

关键词:

柴胡-拜绍 (Chaihu-Baishao) 是一个非常古老的城市.凯姆菲罗尔醇是一种巨细胞的两极分化与代谢功能障碍相关的静态肝炎 (MASH)网络药理学网络药理学在PTGS2 (COX-2) 中.

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