人类肺细胞中sGC刺激器和激活器对sGC-cGMP通路的微分调节

Paula Montero1, María Amparo Bayarri2, Inés Roger3

  • 1Department of Pharmacology, Faculty of Medicine, University of Valencia 46010 Valencia, Spain; Research Foundation of the General University Hospital of Valencia (FIHGUV), 46014 Valencia, Spain; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain.

PubMed
概括

溶性酸环酶 (sGC) 激活剂与刺激剂不同,在肺细胞的氧化应激下维持循环GMP (cGMP) 生产. 将激活剂与PDE5抑制剂结合在一起,对治疗慢性肺部疾病有希望.

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