相关实验视频

Updated: Jul 5, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology

Published on: March 17, 2016

白质微结构和认知衰退在亚急性缺血性中风:从自由水成像和淋巴功能障碍的见解

Yue Qin¹, Xin Li², Lei Wang¹

¹Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Department of Radiology, Xi'an Daxing Hospital Affiliated to Yan'an University, Xi'an, China.

Brain research bulletin

|March 7, 2026

概括

自由水扩散张力成像 (FW-DTI) 在亚急性缺血性中风 (IS) 患者中发现了显著的白质变化. 增加的自由水 (FW) 与认知能力下降有关,可能表明淋巴管功能障碍.

科学领域:

神经成像是一种神经成像.
神经学神经学
生物医学工程生物医学工程

背景情况:

缺血性中风 (IS) 可以导致长期的认知障碍.
评估白质微结构变化对于理解IS病理生理学至关重要.
自由水扩散张力成像 (FW-DTI) 提供了一种新的方法来评估组织的水含量和微观结构完整性.

研究的目的:

用FW-DTI和基于管道的空间统计 (TBSS) 来调查亚急性IS患者的白质微结构变化.
探索这些微观结构变化与认知功能之间的关系.
确定潜在的成像生物标志物用于中风后认知障碍.

主要方法:

39名亚急性IS患者和39名健康对照 (HC) 接受了扩散光谱成像.
使用TBSS分析了自由水 (FW),分数异构 (FA),平均扩散率 (MD) 和FW校正的DTI指标 (FA_T,MD_T).
用蒙特利尔认知评估 (MoCA) 评估认知功能.

主要成果:

与HC相比,IS患者的全脑和白质骨FW显著增加.
在IS患者中观察到减少白质骨FA和FA_T.
在IS患者中增加的FW与MoCA得分负相关,表明认知能力下降.
较高的FW与中风发作后的时间较长有关.
年龄与改变的DTI指标相关,包括增加的FW和MD.

结论:

在亚急性IS中,FW-DTI显示了广泛的白质微结构破坏.
增加的FW可能反映了淋巴功能障碍和血管性.
升高的FW是继缺血性中风后认知障碍的潜在生物标志物.

关键词:

认知障碍认知障碍是一种认知障碍.免费的水图像成像免费的水图像亚急性缺血性中风是什么意思白物质微观结构白物质微观结构

更多相关视频

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

相关概念视频

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Dementia l: Introduction

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...