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股骨软骨厚度的性别相关差异:一个匹配的对分析
Noël Spoelder1, Tom D Turmezei2, Dimitri A Kessler3
1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands; Technical Medicine, University of Twente, Enschede, the Netherlands.
概括
男性的膝盖软骨比女性更厚,即使与身体大小相匹配. 这些基于性别的软骨厚度的差异,特别是在三角质,可能解释了为什么女性更常患膝关节关节炎 (OA).
科学领域:
- 整形外科和运动医学
- 放射学和成像学 放射学和成像学
- 类风湿病学 类风湿病学
背景情况:
- 膝关节关节炎 (OA) 影响女性比男性更频繁.
- 以前的研究表明,两性之间膝关节软骨厚度存在差异,但尚不清楚这些是由于固有的变异或身体大小.
- 了解性别特异性机制对于推进OA研究和治疗至关重要.
研究的目的:
- 量化和可视化男性和女性之间膝关节软骨厚度的差异,没有膝关节放射性OA.
- 在比较中控制年龄和体型 (BMI和身高).
- 调查潜在的软骨形态的性别特异性变异,有助于OA患病率.
主要方法:
- 从骨关节炎倡议 (OAI) 中选择了没有放射性膝关节OA的受试者.
- 男女两对的年龄 (±5岁),BMI (±2kg/m2) 和身高 (±1cm) 均为1:1匹配.
- 使用3TMRI评估软骨厚度,使用隔间分析和3D软骨表面映射 (CaSM),并使用统计参数映射进行比较.
主要成果:
- 分析了126名受试者 (平均年龄为57.7岁).
- 男性在侧面 (p<0.001) 和中间 (p<0.001) 腿骨骨部分的软骨显著比女性更厚.
- 软骨表面测绘显示了五个股骨部区域的显著性别差异,其中三角最明显 (16.1%的差异).
结论:
- 男性的股骨软骨固然比女性更厚,即使年龄和身体尺寸相匹配.
- 三角质区域在软骨厚度上显示出与性别相关的最大差异.
- 在软骨厚度上,这些内在的性别差异可能会导致女性膝关节OA的发病率更高,这凸显了OA研究和临床实践中需要考虑性别特异性的需要.
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