欧洲2020-2024年轻的非发酵的格拉姆阴性细菌 (MINOFEu)
Gabriele Bianco1, Paulo Bastos2, Konstantina Gartzonika3
1Department of Experimental Medicine, University of Salento, Via Provinciale Monteroni n. 165, Lecce, 73100, Italy; Microbiology and Virology Unit, Vito Fazzi Hospital, Lecce, Italy.
International journal of antimicrobial agents
|March 7, 2026
概括
这项研究突出了欧洲医院中微小的非发酵格拉姆阴性菌根 (NFGNB) 的流行病学和抗菌素耐药性. 斯坦诺托福蒙纳斯马尔托菲利亚和阿克罗博巴克特西洛氧化素显示出显著的耐药性模式,需要更新的抗菌战略.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 在欧洲监测中,少量非发酵的格拉姆阴性细菌 (NFGNB),不包括伪虫和青杆菌,代表性不足.
- 了解它们的流行病学和耐药性对于有效的患者管理至关重要.
研究的目的:
- 调查欧洲医院中轻微NFGNB的诊断方法,流行病学和抗菌敏感性.
- 提供最新的概述,支持改进的诊断和抗微生物战略.
主要方法:
- 从血培养中分离的NFGNB微小单元的多中心回顾性观察研究 (2020-2024).
- 对诊断方法 (MALDI-TOF MS),流行病学 (多微生物培养,导管相关的血液感染) 和抗菌素敏感性的分析 (EUCAST指南).
主要成果:
- 4,420个较小的NFGNB分离物被识别出来;其中,Stenotrophomonas maltophilia (52.4%) 和Achromobacter xylosoxidans (7.8%) 是最常见的.
- 观察到S. maltophilia对硫甲醇/trimethoprim (11%) 和A. xylosoxidans对美罗 (10%) 和皮佩拉西林/塔扎巴克坦 (24%) 的高耐药率.
- 发现了特定物种的敏感性模式,其中S. paucimobilis对多种β-乳酸盐和四环素具有很高的敏感性.
结论:
- 这项研究提供了一个全面的欧洲概述小NFGNB诊断和流行病学.
- 这些发现支持需要更新诊断和抗微生物策略,以打击这些病原体的耐药性.
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