综合代谢学和代谢基因组学分析发现了一种独特的特征,它是代谢综合征的特征
Sivaporn Wannaiampikul1, Brian Lee2, Jiarui Chen3
1Thai Canada Research Centre, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand.; Division of Internal Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Ongkharak, Thailand.
The Journal of nutritional biochemistry
|March 7, 2026
概括
代谢综合征 (MetS) 与肠道微生物的减少有关,如Eubacteriaum eligens和较低的内分泌类大麻素NADA. 这种多原子签名为MetS处理提供了潜在的目标.
科学领域:
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
背景情况:
- 代谢综合征 (MetS) 是一个涉及肥胖,高血压,失脂症和胰岛素抵抗的全球健康问题.
- 肠道微生物群影响代谢健康,但特定的微生物与MetS的关联需要进一步定义.
- 遗传,饮食和生活方式因素影响肠道微生物,代谢物和MetS易感性.
研究的目的:
- 确定与代谢综合征 (MetS) 相关的特定微生物和代谢学特征.
- 发现潜在的治疗点,以减轻MetS的负担.
- 通过多原子分析来界定种群特异性特征.
主要方法:
- 相关的临床参数与便转基因组学和142个个体的非向血清代谢学 (97个MetS,45个对照).
- 分析了微生物群物种级别的α多样性.
- 使用共丰富网络分析和sPLS-DA建模.
主要成果:
- 与对照人群相比,在MetS患者中微生物群物种级别的α多样性减少.
- 确定了20种与MetS相关的物种,其中Eubacteria eligens富含控制物.
- 检测到106种不同调节的血清代谢物,特别是N-arachidonoyl多巴胺 (NADA),在对照中丰富,与E. eligens相关.
- E. eligens和D. formicigenerans与NADA和四皮质 (THB) 聚集在一起,区分METS患者.
结论:
- 代谢综合征 (MetS) 呈现出明显的多原子特征.
- 它的特点是减少了E. eligens和D. formicigenerans的丰度.
- 与NADA和THB的循环水平较低有关.
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