在口腔潜在恶性疾病中与口腔上皮质质变形相关的因素:世界卫生组织第五版标准
Amanda de Almeida Lima Borba Lopes1, Letícia Côgo Marques2, Yasmin Peçanha Madureira Corrêa1
1PhD Student, Graduate Program in Pathology, School of Medicine, Universidade Federal Fluminense (UFF), Niterói, Rio de Janeiro, Brazil.
概括
潜在的恶性疾病 (PMD),如白血病等,与口腔上皮质发育不良 (OED) 有关. 损伤位置和异质性是高档OED的关键指标,有助于风险分层.
科学领域:
- 口腔病理学和瘤学
- 牙科医学 牙科医学
- 公共卫生 公共卫生
背景情况:
- 潜在恶性疾病 (PMD) 存在恶性转变的风险.
- 患者特定的因素会影响这种转化风险.
- 了解这些因素对于早期干预至关重要.
研究的目的:
- 研究PMD患者的社会人口统计和临床特征与口腔上皮质质变形 (OED) 之间的关联.
- 为了确定不同程度的OED的风险因素.
- 为了改善口腔癌的风险分层.
主要方法:
- 对患有PMD的患者进行了回顾性横截面研究.
- 分析社会人口统计和临床变量作为预测因素.
- 口腔上皮质质变形症 (OED) 严重程度作为主要结果,分为缺席,轻度,中度或严重.
- 使用基平方或费舍尔精确测试和双变量分析来估计相对风险的统计分析.
主要成果:
- 白血与低级OED (P=.04) 有关.
- 白血病和增殖性白血病 (PVL) 显示中度/重度OED的风险增加 (RR=1.81,P=.04和RR=1.94,P=.05,分别).
- 口腔底部的损伤位置 (P=.03) 和损伤异质性 (P=.05) 与中度/重度OED相关.
结论:
- 虽然PMD类型与OED严重程度有不同的关联,但白血病与低级OED相关.
- 白血病和PVL倾向于更高的OED严重程度.
- 损伤异质性和口腔底部位置是中度/重度OED的重要临床指标,对风险分层至关重要.
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