微针技术近期的进步,在通过皮肤递送药物系统中的微针技术
Anamika Kushwaha1, Lalit Goswami1, Nazanin Amiryaghoubi1
1Department of Chemical Engineering, Chungbuk National University, Cheongju, Republic of Korea, South Korea.
Expert opinion on drug delivery
|March 7, 2026
概括
微针 (MN) 提供了一个有前途的解决方案,以克服皮肤屏障,通过皮肤递送药物系统 (TDD). 这项技术增强了用于疫苗接种,慢性疾病治疗和生物监测的药物输注,为更轻松的自我管理铺平了道路.
科学领域:
- * 制药科学 制药科学
- * 生物医学工程 * 生物医学工程
- * 材料科学 材料科学
背景情况:
- * 透皮药物递送系统 (TDD) 由于角层的屏障功能而面临局限性,限制应用到特定的物理化学性质.
- *微针 (MNs) 是一种非侵入性的方法,通过创建微通道来克服角层屏障,以有效地输入药物.
- * MN技术的进步正在扩大TDD超越传统方法的潜力.
研究的目的:
- * 审查微针技术的近期进展,以通过皮肤递送药物.
- *涵盖微针的设计,材料,制造,优化和表征.
- * 探索微针开发中的各种应用和挑战.
主要方法:
- * 关于微针技术的当前文献的全面审查.
- *分析微针的设计原则,生物材料和制造技术.
- * 探索计算机建模,人工智能驱动的方法,以及在MN开发中的3D打印.
主要成果:
- *微针技术使得疫苗接种,持续药物释放,生物制品,化品和向治疗的有效透皮输送成为可能.
- * 计算机建模,人工智能和3D打印的整合加速了MN设计和制造.
- *确定的关键挑战包括尺寸准确性,安全性,有效性,毒性,可扩展性,监管批准和可持续性.
结论:
- *微针技术显著提高了通过皮肤传递药物,在免疫,慢性疾病管理,缓解疼痛和实时生物监测方面有潜在的应用.
- *未来的发展将优先考虑患者的方便和自我管理,减少对传统针头和医疗保健设施的依赖.
- *克服标准化,校准和持续创新的挑战对于微针成为护理标准至关重要.
相关概念视频
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