甘光提取物的全面评估:消化动力学,肠道微生物群调节和免疫调节机制
Tianjia Jiang1, Rongye Zhu1, Xiuliang Guo2
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China.
Food research international (Ottawa, Ont.)
|March 7, 2026
概括
(Reishi) 提取物经过消化和肠道微生物群的相互作用,影响免疫反应. 提取方法影响稳定性和生物可用性,为功能性食品和精密营养提供了洞察力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 瑞士 (Ganoderma lucidum) 含有诸如β-葡萄糖和甘酸等生物活性化合物,以免疫调节而闻名.
- 口服Ganoderma lucidum提取物的有限生物利用率 (<10%) 是由于消化系统的降解和对肠道微生物群的相互作用不太了解.
- 提取方法对Ganoderma lucidum成分稳定性,消化命运和代谢物概况的影响需要进一步调查.
研究的目的:
- 为了研究水和乙醇Ganoderma lucidum提取物的消化转化和微生物群介导的相互作用.
- 阐明提取方法对Ganoderma lucidum成分的稳定性,生物可用性和免疫调节作用的影响.
- 要了解受甘白影响的"消化-代谢-免疫"级联.
主要方法:
- 使用了体外胃肠道消化模型.
- 在免疫学评估中使用了RAW 264.7巨体测定.
- 进行RNA测序 (RNA-Seq) 来识别关键的调节基因.
主要成果:
- 确定了一种由提取方法,度和消化阶段影响的"消化-代谢-免疫"级联.
- 通过Ganoderma lucidum提取物观察到肠道微生物群的调节,促进抗炎活性和增加结肠芽酸盐的产生.
- 已证明抑制了炎症媒介和调节了与免疫相关的途径,RNA-Seq精确定位了关键的调节基因.
结论:
- 提取方法显著影响了Ganoderma lucidum提取物的稳定性,消化行为和免疫调节潜力.
- 光的提取物,特别是在肠道微生物群调节后,表现出抗炎作用并增强像丁酸盐这样的有益代谢物.
- 这些发现为优化基于甘菌的功能性食品和通过了解"消化-代谢-免疫"轴来推进精密营养策略提供了基础.
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