硬化肌炎 - - 新的前沿
Marie Hudson1, Yves Troyanov2, Océane Landon-Cardinal3
1Division of Rheumatology, Jewish General Hospital, McGill University, 3755 Côte Ste Catherine, Montreal, Quebec, H3T 1E2, Canada.
系统性硬化症 (SSc) 的肌肉参与是主要的表现,而不是与自身免疫性肌肉炎 (AIM) 的重叠. 我们建议使用术语"硬化肌炎" (SM) 来识别这种独特的疾病及其独特的特征.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 在全身性硬化症 (SSc) 中观察到肌肉参与.
- 从临床上来说,区分SSc相关的肌肉问题与其他自身免疫性肌肉炎 (AIM) 是具有挑战性的.
- 肌肉参与SSc的潜在病原体需要进一步阐明.
研究的目的:
- 审查SSc.肌肉参与的临床,血清学和病理学特征.
- 为了区分SSc相关的肌肉疾病与AIM.
- 为这个实体提出一个新的术语 - - 硬化肌炎 (SM),并概述其病原性框架.
主要方法:
- 关于SSc和AIM的综合文献综述.
- 分析临床,血清学和病理学数据.
- 案例研究介绍说明了SM的独特特征.
主要成果:
- 肌肉参与SSc与其他SSc器官表现共享致病机制.
- 建议SSc相关的肌肉疾病作为主要表现,称为硬化肌炎 (SM).
- SM 具有独特的特征,使其与 AIM 有所区别.
结论:
- 硬化肌炎 (SM) 是系统性硬化症 (SSc) 中的一个独特的临床实体.
- 识别SM可以提高对SSc病原和患者管理的理解.
- 鼓励提高人们对"硬化肌炎"一词的认识和一致使用.
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