通过内化障碍的情绪调节来预测治疗结果的神经预测因素:叙事审查
Heide Klumpp1,2, Delaney Davey3, Scott A Langenecker4
1Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA. hklumpp@uic.edu.
Translational psychiatry
|March 7, 2026
概括
在内化障碍中治疗反应的神经预测器正在出现. 显式情绪调节的较低基线活动可能预测更好的治疗结果,而较高的隐式情绪调节活动则表明治疗的益处更大.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理健康 心理健康
背景情况:
- 内化障碍 (例如,抑郁症,焦虑症) 是常见的和使人虚弱的,表现为情绪调节的困难,特别是负面信息.
- 对这些疾病的治疗反应不一致,突出了对个性化方法的需要.
- 治疗反应的神经预测器显示出在精神卫生保健中推进精准医学的前景.
研究的目的:
- 审查功能磁共振成像 (fMRI) 研究,检查明确和隐性情绪调节与内化障碍治疗反应相关的研究.
- 识别神经标记,预测治疗结果在条件,如严重抑郁症,焦虑症和创伤后应激障碍.
主要方法:
- 对调查情绪调节 (明确和隐含) 和治疗反应的fMRI研究进行系统审查.
- 分析重点关注治疗前的神经活动,以应对情绪调节任务期间的负面刺激.
- 考虑常见的治疗方法,包括认知行为疗法,暴露疗法和药物治疗.
主要成果:
- 显式情绪调节 (认知重新评估) 显示在中部和侧部前额皮层预测反应的治疗前活性;较低的基线活性与更大的症状改善相关.
- 隐性情绪调节预测因素通常涉及前额外带状皮层和前额外带状皮层;较高的基线活动通常预测了更大的症状改善.
- 研究结果表明,具有较低基线显式调节能力和较大的隐式调节能力的个体可能从当前的治疗中获益更多.
结论:
- 在情绪调节期间的神经活动是内化障碍治疗结果的相关预测因素.
- 了解明确和隐性情绪调节能力的个体差异可以为精准医学策略提供信息.
- 需要进一步的研究来探索更广泛的内化障碍,并完善神经标记物的预测价值.
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