在人类和鱼类之间传播抗万科素的Enterococcus faecalis和Enterococcus faecium
Yasmine H Tartor1, Mohamed Enany2, Hassnaa M Elsheshtawy3
1Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. jasmen21@yahoo.com.
Scientific reports
|March 7, 2026
概括
抗胺素抗性肠球菌 (VRE) 在鱼类和人类中普遍存在,表现出高水平的多药性耐药性和携带毒性基因. 这凸显了迫切需要加强感染控制和抗生素管理,以防止进一步传播.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 水生动物卫生 水生动物卫生
背景情况:
- 抗菌素耐药性肠球菌 (VRE) 构成了严重的公共卫生威胁.
- 关于鱼群内VRE循环的数据有限.
- 了解鱼类中的VRE对于One Health方法至关重要.
研究的目的:
- 调查发病率,耐药性基因型,毒性因子和VRE在患病的鱼类和人类中的遗传关系.
- 为了比较鱼类和人类隔离物之间的VRE特征.
- 评估与鱼类相关的VRE.的致病潜力和公共卫生影响.
主要方法:
- 多重PCR和MALDI-TOFMS用于VRE识别.
- 抗微生物敏感性测试,包括MDR和XDR表型.
- 查万科米辛耐药性 (vanA,vanB,vanC) 和病毒性基因.
- 多部位序列类型化 (MLST) 用于克隆性评估.
- 在Oreochromis niloticus中的实验性感染模型.
主要成果:
- 在鱼类 (Oreochromis niloticus,Clarias gariepinus) 和人类样本中发现了VRE.
- 在这两种来源中,多耐药性 (MDR) 和广泛耐药性 (XDR) VRE的高患病率.
- 范A基因占主导地位;范B和范C基因也被检测到.
- 许多病毒性基因 (gelE, sprE, asa1, esp, cylA, efa, ace, hyl) 被确定,与VRE物种和宿主有不同的关联.
- MLST揭示了重叠和宿主特定的序列类型.
- 在O. niloticus的实验VRE感染导致显著的死亡率.
结论:
- 该研究证实了鱼类中VRE的循环,与人类VRE共享遗传特征.
- 鱼类VRE中耐药性和毒性因子的高率表明存在潜在的公共卫生风险.
- 建议紧急实施感染控制和抗生素管理,以减轻鱼类和人类之间的VRE传播.
关键词:
菌 (Enterococcus faecalis) 是一种菌.肠球菌 (Enterococcus faecium) 是一个有毒的菌株.抗微生物耐药性 抗微生物耐药性鱼类 鱼类 鱼类 鱼类人类 人类 人类 人类 人类多部位序列的类型化.旺科米辛的耐药性 旺科米辛耐药性病毒性基因是病毒性基因.更多相关视频
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