一个综合的方法阐明了治通的公式来预防缺血性中风
Lina Miao1, Di Zhao1, Liuding Wang1
1National Health Commission Advanced Stroke Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, No. 1 Yard, Xiyuan Playground, Haidian District, Beijing, China.
概括
雄芝通路配方 (XZTLF) 通过减少大脑炎症和氧化应激,显示出治疗缺血性中风 (IS) 的前景. 这种传统中医药可能为IS患者提供新的治疗途径.
科学领域:
- 综合医学是一个整体的医学.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 缺血性中风 (IS) 是一个重大的临床挑战.
- 传统的中国草药处方 - - 雄志通药配方 (XZTLF) 已经显示出对IS的治疗潜力,但其潜在机制需要阐明.
研究的目的:
- 研究XZTLF在治疗缺血性中风 (IS) 中的分子标和机制.
- 通过综合的临床和体内研究来验证XZTLF的疗效.
主要方法:
- 利用网络节点相似性,UPLC-Q-TOF/MS植物化学分析和网络药理学来识别IS目标.
- 通过分子对接和多中心随机对照试验验证实了枢纽基因.
- 评估XZTLF在中脑动脉封闭 (MCAO) 鼠标模型中的疗效,分析生物化学和组织学脑组织标记.
主要成果:
- XZTLF表现出强大的网络接近IS目标,确定了173种生物活性成分.
- 在IS患者中确定并验证了八个核心目标.
- 在MCAO大鼠中,XZTLF治疗显著减少了心脏病发作量,改善了神经功能,减轻了神经炎症,减轻了氧化损伤,并抑制了PI3K/AKT通路.
结论:
- 通过多式调节神经炎症,氧化还原平衡和自途径,XZTLF显示出治疗IS的潜力.
- 综合的临床前和临床初步发现支持XZTLF作为IS的一个有前途的治疗剂.
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