用铜添加的COF触发了通过亡和亡的生物对等协同癌症疗法
Junhe Ou1, Liangmei Yang1, Luwen Zhang1
1School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541001, PR China.
Bioorganic chemistry
|March 8, 2026
概括
这项研究引入了一种用于瘤向治疗的新型铜合平台. 它使用点击化学反应来激活抗癌药物并触发细胞死亡途径,增强癌症治疗.
科学领域:
- 生物医学是生物医学.
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
背景情况:
- 铜催化亚酸循环添加 (CuAAC) 是高效但具有挑战性的瘤向治疗.
- 在瘤微环境中开发用于局部药物激活的平台至关重要.
研究的目的:
- 开发一个合铜的空心共价有机框架 (HCOF@Cu) 平台,用于协同的癌症治疗.
- 能够在现场合成活性抗癌药物,并通过亡和亡诱导瘤细胞死亡.
主要方法:
- 用铜合的空心共价有机框架 (HCOF@Cu) 的制造.
- 在HCOF@Cu平台上同时加载两个无活性前药物.
- 在瘤微环境内进行局部CuAAC反应以激活药物.
- 由嵌入的铜离子触发涉及谷氨 (GSH) 和活性氧物种 (ROS) 的细胞内级联反应.
主要成果:
- 成功地在现场合成活性抗癌药物,抑制瘤生长.
- 铜离子启动了级联反应,消耗GSH并产生ROS.
- 氧化还原干扰导致铁素1 (FDX1) 耗尽和DLAT寡合化.
- 在瘤细胞中诱导协同性亡和亡.
结论:
- 该HCOF@Cu平台有效地整合了CuAAC点击化学和铜离子诱导的级联反应,以加强癌症治疗.
- 这一策略为联合亡和亡诱导提供了一种新的方法,显示出对协同瘤治疗的希望.
更多相关视频
08:22Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
Published on: May 16, 2025
623
19:44Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
Published on: May 30, 2012
19.2K
相关概念视频
Combination Therapies and Personalized Medicine
6.3K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
Cancer Therapies
10.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.5K
