纤维肌痛女性的认知功能障碍和中央敏感症状之间的相互作用:临床相关性和影响
1PMR Department, Health Science University, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.
Journal of psychosomatic research
|March 8, 2026
概括
纤维肌痛中中央敏感性症状与主观认知衰退有关,而不是客观表现. 症状严重程度部分调解了这种关系,强调了患者护理中的认知评估和症状管理.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 心理学 心理学 心理学
背景情况:
- 纤维肌痛 (FM) 是一种经常伴有认知功能障碍的慢性疼痛疾病,通常被称为"纤维雾".
- 中央敏感化 (CS) 是FM病理生理学的关键机制,涉及放大疼痛信号.
- 在FM患者中,CS症状与认知功能之间的关系需要进一步阐明.
研究的目的:
- 为了研究CS症状和主观/客观认知功能之间的关系,在女性的FM.
- 探索疾病严重程度和情感症状对这种关系的影响.
- 确定症状严重程度在CS和认知投诉之间的联系中扮演的调解角色.
主要方法:
- 一项涉及120名根据2016年ACR标准诊断的女性FM患者的横截面研究.
- 使用中央敏感化库存 (CSI),主观认知衰退 (SCD-6) 问卷,蒙特利尔认知评估 (MoCA) 和HADS进行评估.
- 使用回归模型和调解器分析来研究预测因素和调解途径.
主要成果:
- 主观认知衰退 (SCD-6评分) 通过症状严重程度和CSI评分 (R2 = 0.32) 显著预测.
- 客观认知表现 (MoCA) 主要是由多年的教育预测的,CSI的贡献最小.
- 症状严重程度部分介导了CSI和主观认知衰退之间的关系 (间接影响是显著的).
结论:
- 在FM中,主观认知投诉与中央敏感性症状密切相关.
- 这种关联部分归因于整体纤维肌痛症状的严重程度.
- 临床管理应优先考虑FM患者的认知评估和身体症状的有效管理.
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