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从响应声音的脚手架上实时监控药物释放

Sander Spiekhout¹, Bachir A Abeid², Jonathan B Estrada²

¹Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

Ultrasonics sonochemistry

|March 8, 2026

概括

声学响应性支架 (ARS) 允许精确的药物输送. 我们发现,超声波激活产生的低频辐射与药物释放相关,允许实时监测该过程.

科学领域:

生物材料科学生物材料科学
声学工程声学工程
药物输送系统药物输送系统

背景情况:

响应声学支架 (ARS) 提供精确的,超声波触发的药物输送.
目前在实时监测ARS药物释放的局限性存在.

研究的目的:

在基于纤维素的ARS中研究声滴蒸发 (ADV) 机制.
确定滴滴度,声压和爆发数量对ADV动态和药物释放的影响.
建立一种实时监测ARS药物释放的方法.

主要方法:

使用高速光学成像 (5Mfps和50fps) 来观察ADV动态.
在脚手架激活过程中分析了声辐射,特别是低频 (LF) 信号.
与药物释放效率在多个声波爆发中的相关的LF排放变化.

主要成果:

在ADV期间的气泡云形态取决于初始滴滴度.
高度和高压导致气泡云在超声波焦点区域之外扩张高达300%.
明显的低频排放随着反复爆发而减少,与最大有效载荷释放相关,表明蒸发减少.

结论:

低频声波发射提供实时,非侵入性反声波滴滴蒸发在ARSs.
这种相关性使得超声波介导药物输送的有效监测成为可能.
这些发现支持开发具有集成实时释放监控的先进ARS.

关键词:

声学滴滴蒸发的蒸发方式声学监控声学监控声学监控声学监控在声学上响应的脚手架.药物释放释放药物释放药物释放药物阶段转移滴滴的情况.

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