高代谢综合征在唐氏综合征儿童中的流行:需要新的指导方针
Selvamanojkumar Sundaravel1, Neerja Gupta1, Vandana Jain2
1Division of Genetics, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
American journal of medical genetics. Part A
|March 8, 2026
概括
患有唐氏综合征 (DS) 的儿童患有18%的代谢综合征 (MS),明显高于一般人群. 建议从6岁开始对MS,脂质失调和胰岛素抵抗 (IR) 进行早期查.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 唐氏综合征 (DS) 是智力障碍最常见的遗传原因.
- 代谢综合征 (MS) 和其组成部分在儿童中越来越多地被识别出来.
- 关于患有多发性硬化症的儿童中多发性硬化症的患病率的数据有限.
研究的目的:
- 确定患有多发性硬化症的儿童中多发性硬化症的流行率.
- 评估相关的代谢异常,如失脂血症和胰岛素抵抗 (IR).
- 在这个人群中探索身体组成,MS和IR之间的相关性.
主要方法:
- 这是一项涉及114名6-18岁儿童的横截面研究.
- 数据收集包括人口统计,人体测量,禁食血液样本 (葡萄糖,胰岛素,脂质) 和DEXA扫描.
- 代谢综合征使用修改的NCEP-ATP III标准进行分类;IR通过HOMA-IR进行评估.
主要成果:
- 在DS队列中,MS的患病率为18.0%,高于一般人群研究 (5.0%).
- 失脂症在21% (6-9岁) 和15.8% (10-18岁) 观察到;IR在27.6% (10-18岁) 和7.8% (6-9岁) 观察到.
- IR与BMI正相关;总体脂肪量与MS正相关.MS/脱脂症和IR之间没有发现显著的相关性.
结论:
- 与同龄人相比,患有多发性硬化症的儿童患有多发性硬化症的患病率明显高.
- 在患有DS的儿童中,从六岁开始就存在高水平的脂质失调和IR.
- 目前的管理指南可能需要修订,以包括DS儿童的早期代谢查.
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