卵细胞/卵泡计数指数:卵细胞产量最大化是否转化为更好的辅助生殖技术成果?
Shir Danieli-Gruber1,2, Onit Sapir1, Dan Netanely1,2
1Infertility and IVF Unit, the Helen Schneider Hospital for Women, Rabin Medical Center - Beilinson Hospital, Petah Tikva, Israel.
概括
吸收的卵细胞数量超过腹卵泡计数 (AFC) 不会影响新鲜周期的结果,但可能会增加冷保存的卵细胞和胚胎,以保护未来的生育能力或辅助生殖.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 卵巢刺激 卵巢刺激
背景情况:
- 前毛囊数 (AFC) 是卵巢储备的一个关键指标.
- 在辅助生殖技术 (ART) 中,与AFC相比,吸收的卵细胞的最佳数量受到争论.
- 了解这种关系对于最大限度地提高ART周期疗效至关重要.
研究的目的:
- 调查吸收比AFC更多的卵细胞是否有利于当前和未来的ART周期结果.
- 为了比较卵细胞/AFC指数 (OAFCI) <1和≥1.1的组之间的结果.
主要方法:
- 对399次细胞内精子注射 (ICSI) 和283次生育保护 (FP) 周期 (2018-2022) 的回顾性分析.
- 患者根据OAFCI (<1或≥1) 分类.
- 主要结局包括临床妊娠率 (CPR) 和活产率 (LBR);次要结局包括卵细胞成熟率,受精率和冷保存率.
主要成果:
- 卵细胞成熟度在ICSI没有受到影响,但在FP中略低,OAFCI≥1.1.
- OAFCI ≥1与显著更多的冷保存胚胎 (ICSI) 和玻璃化卵细胞 (FP) 有关.
- 在新鲜循环中,OAFCI组之间没有观察到CPR或LBR的显著差异.
结论:
- 吸收比AFC更多的卵细胞不会对新生周期成功率产生负面影响.
- 更高的卵子产量,特别是冷保存时,可能有助于在随后的周期中改善累积怀孕率.
- 这表明,通过增强的冷保存,对未来的生殖潜力有潜在的益处.
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