Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

4.8K
Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
4.8K
Acid Halides to Alcohols: LiAlH4 Reduction01:19

Acid Halides to Alcohols: LiAlH4 Reduction

3.3K
Acid halides are reduced to alcohols in the presence of a strong reducing agent like lithium aluminum hydride.
The mechanism proceeds in three steps. First, the nucleophilic hydride ion attacks the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs as a leaving group, generating an aldehyde. A second nucleophilic attack by the hydride yields an alkoxide ion, which, upon protonation, gives a primary alcohol as...
3.3K
RLC Series Circuit: Problem-Solving01:30

RLC Series Circuit: Problem-Solving

2.8K
Consider an AC generator with a frequency of 50 hertz and a voltage of 120 volts. The AC generator is connected to an RLC series circuit with a 20-ohms resistor, a 0.2-henry inductor, and a 0.05-farad capacitor. Determine the impedance, current amplitude, and phase difference between the generator's current and emf.
To solve the problem, first, determine the known and unknown quantities in the problem. Recalling the reactance equation for the inductor and capacitor and substituting the values,...
2.8K
Kohlraush’s Law and its Applications01:29

Kohlraush’s Law and its Applications

224
 Kohlrausch's law explains that at infinite dilution, where dissociation is complete, each ion's contribution to the conductivity of the electrolyte is independent of the nature of other ions present in the solution. It also implies that when an electrolyte is highly diluted, the conductance of the electrolyte is the sum of the individual conductances of the ions it generates upon dissociation. The quantity of electricity an ion carries is proportional to its molar ionic conductance, which...
224
Radical Equations01:26

Radical Equations

564
Radical equations are mathematical expressions in which the variable is found within a radical, most commonly a square root or cube root. These equations frequently arise in science, engineering, and real-world measurements involving nonlinear relationships. To solve a radical equation, the standard procedure is to isolate the radical expression and then eliminate the radical by raising each side to a power equal to the index of the radical. This process may lead to extraneous...
564
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

21
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

High-flow nasal cannula versus noninvasive ventilation in stabilized hypercapnic exacerbation: a physiological crossover trial.

Annals of intensive care·2026
Same author

Translation of surface electromyography into a clinically applicable objective bulbar assessment tool to improve measurement-based care in amyotrophic laterals sclerosis.

Frontiers in neuroscience·2026
Same author

The effect of nasal patency and anatomy during asymmetrical nasal high flow.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Are teachers missing the beat on students' motor competence?

PloS one·2026
Same author

"What about me? I'm supposed to be … superhuman?": exploring staff perspectives on how to deliver high quality psychological care for people living with amyotrophic lateral sclerosis.

Neurodegenerative disease management·2026
Same author

ALSUntangled #82: N-acetylcysteine.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

An open-label Phase 2a study of fasudil in amyotrophic lateral sclerosis: safety and exploratory endpoints.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

Noninvasive assessment of cardiovascular autonomic reflexes in amyotrophic lateral sclerosis: a systematic review.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

The connection between unproven stem cell-based interventions and complementary and alternative medicine in crowdfunding for Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

Thinning of the oral motor cortex is linked to impaired speech in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

Brain activity in an end-stage ALS patient suggests the presence of an unresponsive wakefulness syndrome.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same journal

Whole-body muscle MRI improves diagnostic certainty in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
查看所有相关文章

相关实验视频

Updated: May 1, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

9.0K

解开ALS #83: 克伦布特罗尔

Adam Burgess1, Olivia Allen2, Paul Barkhaus3

  • 1Department of Neurology, Brooke Army Medical Center, San Antonio, TX, USA.

Amyotrophic lateral sclerosis & frontotemporal degeneration
|March 8, 2026
PubMed
概括
此摘要是机器生成的。

克伦布托罗尔 (clenbuterol) 是一种潜在的对肌缩性侧面硬化症 (ALS) 的治疗方法,在早期研究中显示出可能的益处,但具有显著的副作用. 在推给ALS患者之前,需要进一步的研究.

关键词:
这就是ALS.克伦布醇的使用方法肌肉缩 肌肉缩 肌肉缩神经退行症的神经退行症这是一种β-2上腺激素激动剂,β-2上腺激动剂.

更多相关视频

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 22, 2011

37.6K
Assaying the Kinase Activity of LRRK2 in vitro
06:09

Assaying the Kinase Activity of LRRK2 in vitro

Published on: January 18, 2012

23.9K

相关实验视频

Last Updated: May 1, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

9.0K
A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS
12:43

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 22, 2011

37.6K
Assaying the Kinase Activity of LRRK2 in vitro
06:09

Assaying the Kinase Activity of LRRK2 in vitro

Published on: January 18, 2012

23.9K

科学领域:

  • 药理学 药理学是指药理学的学科.
  • 神经科学是一个神经科学.
  • 肌肉生理学 肌肉生理学

背景情况:

  • 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
  • 目前对ALS的治疗方法有限,这推动了对替代疗法的研究.
  • 克伦布托罗尔是一种β-2上腺激素激动剂,正在研究ALS的潜在治疗效果.

研究的目的:

  • 审查克伦布托罗尔作为治疗肌缩性侧面硬化症 (ALS) 的潜力.
  • 评估与ALS病理生理学相关的克伦布醇的生物效应.
  • 评估在ALS治疗中使用克伦布特的现有证据和局限性.

主要方法:

  • 审查现有的关于克伦布特罗尔效应的文献.
  • 对运动神经元疾病的两项小鼠模型研究的分析.
  • 对两项针对ALS患者的开放性试验的检查.

主要成果:

  • 克伦布托罗尔表现出诸如诱导肌肉缩,改善线粒体功能和减少神经炎症等特性,对ALS有潜在的益处.
  • 在小鼠模型和人体试验中的初步研究表明可能有好处.
  • 目前研究中的方法缺陷限制了最终的结论.
  • 报告了显著和严重的副作用,导致试验和访问计划中的高退学率.

结论:

  • 目前,由于证据不足和安全问题,克伦布托罗尔不能被认可为ALS的有效治疗方法.
  • 进一步严格的研究是有必要的,以探索在ALS患者中使用克伦布醇或类似的β-2上腺激动剂.
  • 必须权衡潜在的益处与不良事件的重大风险.