抵抗训练和皮层下血管认知障碍:一个为期12个月的随机试验
Teresa Liu-Ambrose1,2,3, Ryan S Falck2,3,4, Elizabeth Dao3,5,6
1Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
概括
渐进性抵抗训练 (PRT) 可以改善皮层下血管认知障碍 (SVCI) 的成年人的认知功能. 这项为期12个月的试验发现,PRT显著改善了认知得分,特别是在女性中.
科学领域:
- 神经学 神经学
- 运动科学 运动科学
- 认知健康 认知健康
背景情况:
- 皮下血管认知障碍 (SVCI) 是一种轻度认知障碍的成年人脑小血管疾病的形式.
- 渐进性抵抗训练 (PRT) 对SVCI认知改善的有效性尚未得到充分证实.
研究的目的:
- 研究PRT对SVCI成年人的认知功能的影响.
- 在这个人群中,将PRT与平衡和调节练习 (BAT) 进行比较.
主要方法:
- 一个为期12个月的随机试验,涉及91名SVCI参与者.
- 参与者被分配到PRT或BAT组.
- 认知功能使用阿尔茨海默病评估尺度认知加 (ADAS-Cog-Plus) 进行评估.
主要成果:
- 与BAT相比,PRT显著提高了ADAS-Cog-Plus得分 (平均差异: -0.18;p=0.04).
- 在女性参与者中,PRT的认知益处更为明显.
- 此外,PRT还导致了C-反应蛋白水平的显著降低.
结论:
- 渐进性抵抗训练 (PRT) 对SVCI患者的认知功能有潜在的小但有益的影响.
- 进一步的研究可能会探索对SVCI认知增强的PRT的性别特异性反应.
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