Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.9K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.9K
Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

7.2K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
7.2K
Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

5.4K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
5.4K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.0K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

5.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.7K
Hormones Regulating Blood Glucose01:16

Hormones Regulating Blood Glucose

7.9K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
7.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Real-world insights into neurodevelopmental outcomes amongst people with congenital hyperinsulinism.

Orphanet journal of rare diseases·2026
Same author

Low-level mosaic variants causing the pancreatic disease congenital hyperinsulinism can be detected from blood DNA.

EBioMedicine·2026
Same author

Clinical Presentation and Outcomes of Insulinomas in Pediatric Patients.

Hormone research in paediatrics·2026
Same author

Natural History of the Hyperinsulinism/Hyperammonemia Syndrome: A Retrospective Review Incorporating Patient-Centered Data.

Hormone research in paediatrics·2026
Same author

A High-Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK-Rearranged Non-Small Cell Lung Cancer.

Pediatric blood & cancer·2026
Same author

Extensive Isolated Intracranial Recurrence of Primary Mediastinal B-Cell Lymphoma on FDG PET Imaging.

Clinical nuclear medicine·2026
Same journal

Growth hormone therapy in children born small for gestational age with persistent short stature (SGA-SS): Lessons learned from real-world international databases and directions for future research.

Hormone research in paediatrics·2026
Same journal

Sleep Health and Barriers in Adolescents with Type 1 Diabetes, a Mixed Methods Study.

Hormone research in paediatrics·2026
Same journal

Circulating mRNA and miRNA signatures used as predictive markers of lifestyle modification outcomes in pediatric obesity management.

Hormone research in paediatrics·2026
Same journal

Functional impact of a novel intronic TG variant in congenital goiter and thyroid dyshormonogenesis.

Hormone research in paediatrics·2026
Same journal

Efficacy and Safety of Somapacitan vs Daily Growth Hormone in Children with Growth Hormone Deficiency: A Pooled Analysis of Randomised Trial Data.

Hormone research in paediatrics·2026
Same journal

Cerebral X-Linked Adrenoleukodystrophy Associated with Hemophilia A: a case report.

Hormone research in paediatrics·2026
查看所有相关文章

相关实验视频

Updated: Mar 10, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

96.0K

双重问题:当焦点和扩散的高胰岛素症同时发生时.

Victoria R Sanders, Katherine Lord, Winnie Sigal

    Hormone research in paediatrics
    |March 8, 2026
    PubMed
    概括
    此摘要是机器生成的。

    先天性高胰岛素症 (HI) 在同一位患者中可以呈现为焦点和扩散形式. 切除焦点病变的手术可能需要二氧化来控制剩余的扩散性疾病.

    更多相关视频

    Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
    08:47

    Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

    Published on: December 7, 2017

    10.3K
    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
    08:32

    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

    Published on: January 4, 2018

    11.0K

    相关实验视频

    Last Updated: Mar 10, 2026

    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
    11:10

    Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

    Published on: November 16, 2011

    96.0K
    Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
    08:47

    Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

    Published on: December 7, 2017

    10.3K
    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
    08:32

    Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

    Published on: January 4, 2018

    11.0K

    科学领域:

    • 内分泌学 在内分泌学.
    • 儿科手术 儿科手术
    • 医学遗传学 医学遗传学

    背景情况:

    • 先天性高胰岛素症 (HI) 通常被分为对氧化有反应或没有反应.
    • 氧化物不响应的HI进一步分为扩散或焦点形式,每种形式都有不同的管理方法.
    • 虽然通常呈现为单个形式,但可以同时发生焦点和扩散HI.

    研究的目的:

    • 报告三名患有同时存在焦点和扩散先天性高胰岛素症的患者.
    • 为了突出诊断和管理策略,为这个复杂的演示.
    • 强调焦点病变切除后持续评估的重要性.

    主要方法:

    • 三名患者的病例系列,具有对二氧化无反应的HI.
    • 使用18-F-L-DOPA正子发射断层扫描来识别焦点损伤.
    • 进行了焦点病变的手术切除,随后进行了他的病理学分析.
    • 进行了禁食研究和基因测试以鉴定疾病特征.

    主要成果:

    • 这三名患者均呈现了对氧化无反应的HI和同时存在的焦点和扩散性疾病.
    • 18-F-L-DOPA PET在所有病例中都发现了焦点胰腺病变.
    • 切除焦点病变的手术切除并没有完全消除过胰岛素症,这表明持续的扩散性疾病.
    • 在这些患者中,用氧化物进行切除后的管理对正在进行的HI有效.

    结论:

    • 焦点性和扩散性先天性高胰岛素症可以同时发生在同一个患者身上.
    • 仔细的术后评估对于在焦点病变切除后检测剩余的高胰岛素水平至关重要.
    • 在这种情况下,基因分析和氧化可能是管理持续性HI的必要条件.