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在肺鱼嗅觉器官的产后发育过程中,2型鼻受体表达的变化

Shoko Nakamuta¹, Zicong Zhang², Masato Nikaido³

¹Laboratory of Veterinary Anatomy, Faculty of Veterinary Medicine, Iwate University, Morioka, Japan.

Journal of anatomy

|March 8, 2026

概括

肺鱼V2R基因表达表明,嗅觉器官 (嗅觉上皮和内上皮) 在生长过程中变得更加明显. 这表明脊椎动物双模嗅觉系统的发育过程.

科学领域:

进化生物学是进化的生物学.
神经科学是一个神经科学.
比较解剖学的比较解剖学.

背景情况:

四足动物有两个嗅觉器官:嗅觉上皮 (OE) 和口鼻器官 (VNO).
肺鱼是四足动物的近亲,它们具有层状OE和原始VNO (回表皮,ReCE).
肺鱼中的口腔鼻腔受体2型 (V2R) 基因是根据它们的表达方式分类的. 状OE,Rece,或两者兼而有之.

研究的目的:

为了研究成长过程中肺鱼 (Protopterus annectens) V2R基因表达模式的变化.
了解脊椎动物双模嗅觉系统的发育过程.

主要方法:

在不同体型的肺鱼中比较V2R表达模式.
分析V2R基因表达局部在状OE和Rece中的分析.

主要成果:

在小个体中,V2Rs仅在状OE或Rece中存在,在大个体中仍然是组织特异性的.
最初在小肺鱼的两个组织中表达的V2Rs在大个体中表现出不同的模式:一些在两者中保持,而另一些则成为Rece特异性.
中等大小的个体表现出中间表达模式,表明成熟期间的逐渐转变.

结论:

随着肺鱼的成熟,V2Rs的一个子集从双表达过渡到Rece特异表达,这表明幼鱼的功能分离不完全.
叶片OE和Rece之间的功能分离随着肺鱼的生长而变得更加明显.
这些发现支持了脊椎动物双节嗅觉系统的发育过程的假设,可能是从共同祖先的非分离状态进化而来的.

关键词:

进化演化演化演化演化演化演化演化在现场混合化.肺鱼是一种肺鱼.产后发育产后发育吐是一种鼻腔器官.吐鼻腔受体的使用

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