埃舍里奇亚大肠杆菌ST131驱动卡巴胺 用于E. coli 血流感染
Natalie A Mackow1, Wanying Shao2, Lizhao Ge2
1Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, NC, United States of America.
概括
耐塞夫特里亚克森的大肠杆菌感染越来越多地是由ST131菌株,特别是C2/H30Rx亚类驱动的. 这一发现凸显了对这些耐药性感染的更新治疗策略的需要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 耐塞夫特里亚克森的大肠杆菌 (大肠杆菌) 感染是一个日益严重的公共卫生问题.
- 大肠杆菌序列131型 (ST131) 的出现,特别是其产生扩展光谱β-乳酸酶 (ESBL) 的C2/H30Rx亚类,是这种增长的关键因素.
研究的目的:
- 为了比较由大肠杆菌ST131与非ST131菌株引起的血液感染 (BSI).
- 专门研究涉及大肠杆菌ST131 C2/H30Rx亚类的感染的特征和结果.
主要方法:
- 在14个美国地点进行了前性队列研究.
- 单微生物大肠杆菌的BSI病例 (耐和易受) 在1:1的比例上被纳入.
- 结果排名的可取性 (DOOR) 被评估在感染后的30天.
主要成果:
- 大肠杆菌ST131占大肠杆菌BSI病例的43%,其中23%属于C2/H30Rx亚类.
- 与非ST131菌株 (27%) 相比,ST131 (79%) 和C2/H30Rx (86%) 菌株中抗素耐药性显著更高.
- 患有ST131 BSI的患者年龄较大,更可能来自长期护理机构,并接受了更多的卡巴胺治疗.
结论:
- 大肠杆菌ST131菌株,特别是C2/H30Rx亚分类,是美国抗塞夫克松的大肠杆菌血流感染的主要驱动因素.
- 这些发现强调了ST131在需要增加卡巴因的治疗耐药大肠杆菌感染时的重要性.
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