来自内菌Cladosporium tenuissimum的两个新的12个成员的宏和它们的生物活性
Li-Bin Lin1, Jing-Yu Wang1, Dan Shen1
1Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Baoji 721013, Shaanxi, P. R. China.
Chemical & pharmaceutical bulletin
|March 8, 2026
概括
对Cladosporium tenuissimum的化学分析揭示了具有显著抗真菌和α-葡萄糖酶抑制活性的新型宏类. 一种化合物表现出显著的细胞毒性,表明开发新治疗剂的潜力.
科学领域:
- 自然产品化学 自然产品化学
- 药用化学 医学化学
- 菌类学 菌类学是指菌类学.
背景情况:
- Cladosporium tenuissimum是一种已知产生生物活性二次代谢产物的真菌物种.
- 麦克罗利德是一种具有多种生物活动的化合物.
研究的目的:
- 从Cladosporium tenuissimum中分离和描述新的类.
- 评估这些代谢产物的细胞毒性,抗真菌和α-葡萄糖酶抑制活性.
主要方法:
- 使用全面的光谱技术进行化学分析.
- 电子循环二元化 (ECD) 计算和莫舍尔分析以确定绝对配置.
- 细胞毒性,抗真菌和α-葡萄糖酶抑制的生物测试.
主要成果:
- 分离了六种12个成员的宏化物,其中包括两种新化合物 (1和2).
- 化合物1,4和5对Alternaria solani和Botrytis cinerea表现出中度至强度的抗真菌活性.
- 化合物6显示出显著的α-葡萄糖酶抑制,表现优于阳性对照acarbose.
- 化合物7显示对HeLa细胞的中度细胞毒性.
结论:
- 这项研究发现了来自Cladosporium tenuissimum的新生物活性宏化物.
- 这些化合物显示出开发作为抗真菌剂,α-葡萄糖酶抑制剂和细胞毒药物的潜力.
- 需要进一步的研究来探索这些代谢物的治疗潜力.
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