[在偶发性髓性甲状腺癌中对甲状腺切除术和全甲状腺切除术的比较分析]
1Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,China.
Zhonghua yi xue za zhi
|March 8, 2026
概括
甲状腺膜切除术 (HT) 和全甲状腺切除术 (TT) 对散发性髓性甲状腺癌 (sMTC) 的治疗效果相似. 选择性HT是安全的和可行的,经过仔细的手术前评估,提供与TT类似的结果.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 甲状腺癌研究研究
背景情况:
- 散发性髓性甲状腺癌 (sMTC) 的治疗策略需要仔细考虑手术程度.
- 对比甲状腺切除术 (HT) 和全甲状腺切除术 (TT) 对于优化SMTC患者的治疗结果至关重要.
研究的目的:
- 为了比较甲状腺膜切除术 (HT) 与甲状腺全切除术 (TT) 的治疗效果,在患有偶发性髓性甲状腺癌 (sMTC) 的患者中.
- 评估选择性HT在sMTC管理中的安全性和可行性.
主要方法:
- 从2011年至2019年期间接受治疗的199名smtc患者的临床数据的回顾性审查.
- 倾向性得分匹配 (PSM) 用于平衡HT和TT组之间的基线特征.
- 生物化学治愈率,复发率,无进展生存期 (PFS) 和整体生存期 (OS) 的比较.
主要成果:
- 在PSM之前,HT显示出比TT更高的生化治愈率和更长的PFS,但在复发率或OS上没有显著差异.
- 在PSM之后,在生物化学治愈率,复发率,PFS或OS方面,在HT和TT组之间没有观察到统计学上显著的差异.
- 在PSM之前,手术前的色素,N阶段,TNM阶段和病变数量在PSM前的组之间有显著差异.
结论:
- 甲状腺膜切除术 (HT) 和全甲状腺切除术 (TT) 在散发性骨髓性甲状腺癌 (sMTC) 中显示出相似的治疗效果.
- 选择性甲状腺切除术 (HT) 是对sMTC的一种安全和可行的选择,当与精心的手术前评估一起进行时.
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