孕产妇Bacillus益生菌通过脏IGF-1/mTOR和FOXO1/IL-10通道调节后代的生长和免疫力
Tahany Saleh Aldayel1, Heba M A Abdelrazek2, Nadia A El-Fahla3
1Department of Health Sciences, Clinical Nutrition, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, PO Box 84428, 11671, Riyadh, Saudi Arabia.
Scientific reports
|March 9, 2026
概括
孕妇在怀孕期间服用益生菌 (Bacillus clausii) 补充剂,尤其是在早期,显著促进了后代的生长和免疫发育. 早期的益生菌暴露改善了年轻小鼠的脏健康和关键免疫标志物.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 发展生物学 发展生物学
背景情况:
- 孕产妇服用益生菌可能会影响后代的微生物平衡,生长和免疫系统发育.
- 了解孕产妇益生菌干预的最佳时间对于最大化益处至关重要.
- 早期的免疫编程对于长期的健康结果至关重要.
研究的目的:
- 为了评估母亲在不同怀孕阶段*Bacillus clausii*补充剂对28天大时男性后代生长和免疫发育的影响.
- 研究对血液学概况,血清免疫因子,脏特征和特定分子标记物 (mTOR,IGF-1,FOXO1) 的影响.
主要方法:
- 怀孕的小鼠在孕期第0,第8或第16天与对照组一起接受了*Bacillus clausii* (1x10^9 CFU).
- 后代的体重,脏体重,脏体质指数 (SSI),血液学,以及GH,IGF-1,TNF-α,IFN-γ,IL-10,IgA和IgG的血清水平进行了评估.
- 分析了脏的mTOR表达 (qPCR,ELISA) 和IGF-1和FOXO1.1的免疫组织化学染色.
主要成果:
- 孕期0日 (GD0组) 给母亲服用益生菌显著增加了后代的体重,脏体重,SSI,GH,IGF-1,IL-10,IgA和IgG水平.
- GD0组表现出TNF-α和IFN-γ水平的降低,表明向更受调节的免疫反应转变.
- 在GD0组中观察到增强的脏免疫细胞结构,升高的IGF-1和减少的FOXO1表达,这表明免疫系统改造的改善.
结论:
- 早期的母体益生菌补充 (*GD0上的Bacillus clausii*) 可以积极调节后代的生长和免疫系统的发展.
- 这种干预增强了淋巴细胞的活动,并促进了脏免疫系统的重塑,这对于早期的免疫编程至关重要.
- 孕产妇服用益生菌是一种优化后代免疫健康的有希望的策略.
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