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先进的酸盐-营养体,用于增强发酵的Echium amoenum多的口服输送
Ehsan Divan Khosroshahi1, Rita Abi Rached2, Angela Serpe3
1Faculty of Agricultural Engineering and Technology, Bioprocess Engineering Laboratory (BPEL), Department of Food Science and Engineering,, University of Tehran, Karaj, 31587-77871, Iran.
Scientific reports
|March 9, 2026
概括
发酵和纳米载体技术增强了Echium amoenum多,使其更好地吸收. 酸盐-营养素体显示出可以口服输送这些改进的生物活性化合物的前景.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 食品科学 食品科学 食品科学
背景情况:
- 埃奇乌姆阿蒙 (Echium amoenum) 是一种富含多的药用植物,生物利用率低 (5-10%).
- 微生物发酵和纳米载体系统可以提高多的生物可用性和有效性.
- 乳酸发酵和脂囊泡提供了改善E. amoenum提取物传递的潜力.
研究的目的:
- 开发一种使用乳酸发酵和基于脂的纳米载体的综合方法,以优化E. amoenum提取物的输送.
- 评估装有发酵E. amoenum提取物的纳米载体的特性,稳定性和体外性能.
主要方法:
- 使用Lactiplantibacillus plantarum.使用E. amoenum提取物的乳酸发酵.
- 将发酵提取物纳入脂质体,营养体和酸盐-营养体.
- 使用冷TEM,FTIR,尺寸,电荷,PDI和负载效率进行表征.
- 在模拟的胃肠道条件下的稳定性评估和体外释放研究.
- 对Caco-2细胞的生物相容性和保护作用的评估.
主要成果:
- 发酵的E. amoenum提取物成功地被封装在脂质体,营养体和酸盐营养体中,具有高负载效率 (>90%).
- 所有纳米载体都是纳米大小 (105-124 nm),负电荷 (~ -56 mV),在模拟生理条件下稳定.
- 观察到受控释放的特征,以及对Caco-2细胞的生物相容性和保护作用.
结论:
- 酸盐-营养素体是一种有前途的纳米载体,可用于口服发酵的E. amoenum提取物.
- 发酵和纳米载体封装的结合方法显著提高了生物活性多的输送.
- 这一策略有可能提高E. amoenum在各种应用中的治疗效果.
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