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Updated: Mar 10, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

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合成,表征,分子对接和一些基于thioxoacetamides的新型spiro [1,3,4] thiadiazole衍生物的体外抗关节炎活性

Ahmed M El-Saghier1, Asmaa Abdul-Baset2, Omar M El-Hady2

  • 1Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt. el.saghier@science.sohag.edu.eg.

BMC chemistry
|March 9, 2026
PubMed
概括

新的spirothiadiazole衍生物显示出作为抗关节炎药物的显著潜力. 化合物9a在抑制蛋白质变性方面表现出最高的功效,这表明它是关节炎治疗的有希望的治疗途径.

关键词:
具有抗关节炎活性.分子对接和COX-2抑制螺旋二二醇的使用方法氧乙胺的使用方法

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