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生物衰老部分调解了身体活动和膀过度活跃之间的关联:来自NHANES 2007-2020年的证据
Junlong Huang1, Pingting Chen1, Jiayi Zhuang1
1Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, P. R. China.
Clinical epigenetics
|March 9, 2026
概括
身体活动 (PA) 可以通过减缓生物衰老来预防过度活动的膀 (OAB). 它还降低了OAB患者的死亡风险,强调了它在OAB管理中的重要性.
科学领域:
- 老年学是一门学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 公共卫生 公共卫生
背景情况:
- 过度活跃的膀 (OAB) 显著影响生活质量,并与增加的死亡率有关.
- 身体活动 (PA) 对OAB的保护作用和生物衰老的调解作用需要进一步研究.
研究的目的:
- 检查PA,生物衰老,OAB和全因死亡率之间的关联.
- 测试生物衰老是否调解了PA和OAB之间的关系.
主要方法:
- 利用来自国家健康和营养检查调查 (2007-2020) 的数据,加权Cox和后勤回归.
- 使用PhenoAge和KDMAge加速指标评估生物衰老.
- 采用调解分析来探索生物衰老在PA-OAB关系中的作用.
主要成果:
- 在OAB患者中,OAB增加了全因死亡风险 (HR 1.430),而PA降低了OAB患者的死亡率 (HR 0.572).
- PA与OAB风险降低相关 (OR为0.856),而增加的PhenoAge和KDMAge加速与较高的OAB风险相关.
- 调解分析表明,PA减缓了PhenoAge (13.47%) 和KDMAge (2.71%) 的加速,从而降低了OAB风险.
结论:
- 身体活动可以通过减缓生物衰老来降低OAB发生率.
- 在患有OAB的个体中,PA可以降低全因死亡率.
- 这些发现强调了PA作为OAB的预防和管理策略的潜力.
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