DENND2D作为一种新的预后生物标志物,在质瘤中具有矛盾的原始原始效应
Hongxing Ye1, Chao Zhang1, Linghao Bu1
1Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Discover oncology
|March 9, 2026
概括
DENND2D是一种致癌基因,驱动着质瘤的攻击性和免疫抑制. 高DENND2D水平表明预后不佳,并代表着质母细胞瘤的潜在治疗点,为抗免疫疗法耐药性提供希望.
科学领域:
- 神经瘤学神经瘤学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 质瘤,特别是质母细胞瘤 (GBM),在临床上是一个重大挑战,有效的治疗选择有限.
- 识别新的分子标对于改善GBM患者的治疗结果至关重要.
研究的目的:
- 研究DENND2D (DENN域含蛋白2D) 作为质瘤中潜在的分子点的作用.
- 分析DENND2D表达模式及其与质瘤进展和患者存活率的相关性.
主要方法:
- 分析了来自TCGA,CGGA和GTEx数据库的RNA测序数据.
- 方法包括生存分析,甲基化/复制数分析,权重基因共同表达网络分析 (WGCNA) 和免疫细胞透分析 (CIBERSORT).
主要成果:
- DENND2D在高度质瘤中显著上调,并与预后不良的因素相关 (IDH野生型,非-1p/19q-codeletion).
- 高DENND2D表达与更差的生存率相关,并且与促进体甲基化相反相关.
- DENND2D与免疫调节剂共同表达,并与免疫抑制性免疫细胞透物有关,包括巨细胞和T细胞.
结论:
- DENND2D在质瘤中起着瘤基因的作用,促进瘤的攻击性,并创造了一个免疫抑制瘤微环境.
- DENND2D作为一种新的预后生物标志物,也是增强质瘤免疫疗法疗效的有希望的治疗标.
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